89482-39-3Relevant academic research and scientific papers
Cobalt-Catalyzed Allylation of Amides with Styrenes Using DMSO as Both the Solvent and the α-Methylene Source
Zhang, Xu,Zhou, Zhi,Xu, Huiying,Xu, Xuefeng,Yu, Xiyong,Yi, Wei
supporting information, p. 7248 - 7253 (2019/10/08)
An efficient synthesis of privileged allylic amines has been developed via cobalt-catalyzed allylation of amides with styrenes, in which DMSO was used as both the solvent and the α-methylene source. This transformation features high yields, and selectivity for the (E)-isomer of the linear product. Through the experimental and computational investigations, a sequential K2S2O8-mediated oxidative coupling/cobalt-assisted regioselective alkene insertion/β-H elimination/alkene dissociation/hydride transfer process has also been deduced.
Electrocyclic Aromatic Substitution by Nitrile Ylides to give 3H-2-Benzazepines: Substituent Effects and Mechanism
Groundwater, Paul W.,Sharp, John T.
, p. 7951 - 7964 (2007/10/02)
Benzonitrile 3,3-diarylallyl nitrile ylides (16), generated by the base-induced dehydrochlorination of imidoyl chlorides, cyclised by 1,7-ring closure to give 3H-2-benzazepines e.g. (19), in contrast to analogous diazo-compounds (1) which prefer 1,5-elect
N-LITHIO-N-(2-LITHIOETHYL)- AND N-LITHIO-N-(3-LITHIOPROPYL)-BENZAMIDE: DIRECT PREPARATION AND SYNTHETIC APPLICATIONS OF 2-LITHIOETHYL- AND 3-LITHIOPROPYL-AMINE EQUIVALENTS
Barluenga, Jose,Foubelo, Francisco,Fananas, Francisco J.,Yus, Miguel
, p. 2183 - 2192 (2007/10/02)
The successive reaction of 2-chloroethyl and 3-chloropropyl-benzamide with n-butyl-lithium and lithium naphthalenide at temperatures ranging between -78 and -50 deg C leads to N-lithio-N-(2-lithioethyl)- and N-lithio-N-(3-lithiopropyl)benzamide , which by treatment with different electrophiles (H2O, D2O, Me2S2, CO2, PriCHO, PhCHO, Me2CO, Ph2CO, and O2) yields the expected functionalized benzamides .The acidic and basic hydrolysis of compounds (10) and (11) gives different results depending on the structure of the substrate and the reaction conditions.
