1426336-63-1

Basic information

• Product Name: (S)-6-((1-amino-1-oxopropan-2-yl)amino)-2-(2-(2-aminopyridin-4-yl)-4-chlorophenoxy)pyrimidine-4-carboxamide
• Synonyms: (S)-6-((1-amino-1-oxopropan-2-yl)amino)-2-(2-(2-aminopyridin-4-yl)-4-chlorophenoxy)pyrimidine-4-carboxamide
• CAS NO: 1426336-63-1
• Molecular Weight: 427.85
• Mol File: 1426336-63-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-6-((1-amino-1-oxopropan-2-yl)amino)-2-(2-(2-aminopyridin-4-yl)-4-chlorophenoxy)pyrimidine-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-6-((1-amino-1-oxopropan-2-yl)amino)-2-(2-(2-aminopyridin-4-yl)-4-chlorophenoxy)pyrimidine-4-carboxamide(1426336-63-1)
• EPA Substance Registry System: (S)-6-((1-amino-1-oxopropan-2-yl)amino)-2-(2-(2-aminopyridin-4-yl)-4-chlorophenoxy)pyrimidine-4-carboxamide(1426336-63-1)

Safety Data

• Hazardous Substances Data: 1426336-63-1(Hazardous Substances Data)

Upstream product

• 6299-85-0 2,6-dichloropyrimidine-4-carboxylic acid methyl ester 
• 1426337-12-3 (S)-methyl 2-chloro-6-((1-methoxy-1-oxopropan-2-yl)amino)pyrimidine-4-carboxylate 
• 1235406-61-7 2-(2-aminopyridin-4-yl)-4-chlorophenol 
• 1426337-13-4 (S)-6-((1-amino-1-oxopropan-2-yl)amino)-2-chloropyrimidine-4-carboxamide 
• 19798-80-2 2-Amino-4-chloropyridine 
• 89488-25-5 (5‐chloro‐2‐hydroxyphenyl)boronic acid 
• 65-86-1 orotic acid 
• 26830-94-4 2,4-dichloropyrimidine-6-carboxylic acid chloride 
• 98136-42-6 2,6-dichloropyrimidine-4-carboxamide 

Relevant articles and documents

PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS

The present disclosure provides substituted pyrimidine carboxamides of Formula (I) and the pharmaceutically acceptable salts and solvates thereof, wherein A1, X, A2, W1, W2, W3, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.