895-06-7Relevant academic research and scientific papers
Synthesis of metal-based analogues of isonicotinoyl and benzoyl hydrazones and their antioxidant and cytotoxic activities
Shafiq, Zahid,Hussain, Mazhar,Yaqub, Muhammad,Shafiq, Kiran,Ashraf, Mohammad,Ahmad, Hafiz Badaruddin
experimental part, p. 4623 - 4628 (2012/08/28)
A series of 20 metal based [Cu(II), Co(II), Ni(II), Mn(II) and Zn(II)] compounds have been synthesized with novel 2,5-dihydroxyacetophenone isonicotinoyl hydrazone (L1) and 2,5-dihydroxyacetophenone benzoyl hydrazone (L2) Schiff bases and were screened for antioxidant and cytotoxic activities. All these complexes exhibited strong antioxidant activity against DPPH radical but no nitric oxide radical scavenging activity. Cytotoxicity assay showed toxicity at varied levels, that is, 1, 3, 7, 11, 15 showed maximum toxicity and 4, 9, 10, 12, 13, 16, 19, 20 showed minimal cytotoxicity against brine shrimp larvae. Antibacterial activity assay exhibited MIC50 values of 2, 4, 6, 8, 10, 12, 14, 16, 18, 20 comparable to standard drugs for both gram-positive and gram-negative bacteria whilst other compounds showed minimal activity against these bacteria. Structure activity relationship shows the role of metal and the kind of complex associated with the said biological activities.
Synthesis of hydrazones schiff bases and microbiological evaluation of lsonicotinoyl hydrazide with different acetophenone
Kelode,Mandlik,Aswar
scheme or table, p. 1053 - 1062 (2012/04/04)
A series of hydrazones Schiff bases compounds have been synthesized by reacting isonicotinoyl hydrazide with 2-hydroxy-5-chloro acetophenone, 2-hydroxy-5-methyl acetophenone, 2-hydroxy-5-carboxy acetophenone, 2,5-dihydroxy acetophenone, 2-hydroxy-5-chloro-4-methyl acetophenone, 2-hydroxy-5-chloro-3- nitro acetophenone, 2-hydroxy-5-methyl-3-nitro acetophenone and 2-hydroxy-5-bromo acetophenone. The Schiff bases have been evaluated for the antifungal and antibacterial activities.
Schiff base metal complexes of chromium(III), manganese(III), iron(III), oxovanadium(IV), zirconium(IV) and dioxouranium(VI)
Mandlik,Aswar
, p. 129 - 135 (2007/10/03)
The Schiff base 2,5-dihydroxyacetophenone isonicotinoyl hydrazone (H2L) has been synthesized by condensation of 2,5-dihydroxyacetophenone with isonicotinoyl hydrazide in ethanol. Metal complexes of the Schiff base were prepared from salts of Cr
