895-61-4

Basic information

• Product Name: 6,7-DIHYDROXYCOUMARIN-7-BENZYL ETHER
• Synonyms: ESCULETIN-7-BENZYL ETHER;7-BENZYL-O-ESCULETIN;7-BENZYLOXY-6-HYDROXY-CHROMEN-2-ONE;7-BENZYLOXY-6-HYDROXYCOUMARIN;6,7-DIHYDROXYCOUMARIN-7-BENZYL ETHER
• CAS NO: 895-61-4
• Molecular Formula: C₁₆H₁₂O₄
• Molecular Weight: 268.26
• Mol File: 895-61-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 503.8 °C at 760 mmHg
• Flash Point: 193.7 °C
• Appearance: /
• Density: 1.339 g/cm³
• Vapor Pressure: 8.97E-11mmHg at 25°C
• Refractive Index: 1.647
• CAS DataBase Reference: 6,7-DIHYDROXYCOUMARIN-7-BENZYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-DIHYDROXYCOUMARIN-7-BENZYL ETHER(895-61-4)
• EPA Substance Registry System: 6,7-DIHYDROXYCOUMARIN-7-BENZYL ETHER(895-61-4)

Safety Data

• Hazardous Substances Data: 895-61-4(Hazardous Substances Data)

Usage

Uses

7-Benzyl-O-esculetin is a derivative of Esculetin. Esculetin acts as an anti-HCV agent. As a non-nutrient phytocchemical it plays a role in chemopreventative and anti-tumor activity in vivo.

InChI:InChI=1/C16H12O4/c17-13-8-12-6-7-16(18)20-14(12)9-15(13)19-10-11-4-2-1-3-5-11/h1-9,17H,10H2

Upstream product

• 305-01-1 aesculetin 
• 100-44-7 benzyl chloride 
• 441325-55-9 4-benzyloxy-2,5-dihydroxybenzaldehyde 
• 108-24-7 acetic anhydride 

Downstream Products

• 305-01-1 aesculetin 
• 169870-01-3 6-β-D-galactopyranosyloxy-7-hydroxy-coumarin 
• 531-75-9 esculin 
• 92-61-5 7-hydroxy-6-methoxy-2H-1-benzopyran-2-one 
• 34340-36-8 7-benzyloxy-6-β-D-galactopyranosyloxy-coumarin 
• 34340-36-8 7-benzyloxy-6-β-D-glucopyranosyloxy-coumarin 
• 95055-91-7 7-Benzyloxy-6-[2-(3,4-dimethoxy-phenyl)-2-hydroxy-1-methyl-ethoxy]-chromen-2-one 
• 95055-93-9 (2S,3S)-3-(3,4-Dimethoxy-phenyl)-2-methyl-2,3-dihydro-1,4,5-trioxa-anthracen-6-one 
• 95055-92-8 6-[2-(3,4-Dimethoxy-phenyl)-2-hydroxy-1-methyl-ethoxy]-7-hydroxy-chromen-2-one 
• 95055-90-6 6-O-(3,4-Dimethoxy-α-methylphenacyl)-7-O-benzylesculetin 
• 34340-35-7 7-benzyloxy-6-(tetra-O-acetyl-β-D-glucopyranosyloxy)-coumarin 
• 101451-75-6 7-(benzyloxy)-6-methoxy-2H-chromen-2-one 

Relevant articles and documents

PROCESS FOR PREPARATION OF ESCULETIN COMPOUNDS, ESCULETIN COMPOUNDS AND INTERMEDIATES THEREOF, AND USE OF BOTH

An esculetin compound, an intermediate thereof, a process for manufacturing an esculetin compound, and an antifungal composition for agriculture and horticulture and an herbicide comprising an esculetin compound or an intermediate thereof are provided. The process for manufacturing an esculetin compound is a low-cost, high-yield, and industrially practicable process, and comprises the following step.A process for manufacturing an esculetin compound of the formula (2): characterized by cyclizing a trihydroxybenzaldehyde compound of the formula (1): in an aprotic polar solvent in the presence of a weak base, with acetic anhydride or the like.