89508-14-5

Basic information

• Product Name: 2,6-Piperazinedione, 4-(cyclohexylcarbonyl)-1-[2-(2-thienyl)ethyl]-
• CAS NO: 89508-14-5
• Molecular Formula: C17H22N2O3S
• Molecular Weight: 334.439
• Mol File: 89508-14-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,6-Piperazinedione, 4-(cyclohexylcarbonyl)-1-[2-(2-thienyl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Piperazinedione, 4-(cyclohexylcarbonyl)-1-[2-(2-thienyl)ethyl]-(89508-14-5)
• EPA Substance Registry System: 2,6-Piperazinedione, 4-(cyclohexylcarbonyl)-1-[2-(2-thienyl)ethyl]-(89508-14-5)

Safety Data

• Hazardous Substances Data: 89508-14-5(Hazardous Substances Data)

Upstream product

• 40412-06-4 2-(2-thienyl)ethyl tosylate 
• 87693-73-0 4-(cyclohexylcarbonyl)-2,6-dioxopiperazine 

Downstream Products

• 89508-18-9 4-cyclohexylcarbonyl-6-hydroxy-1-<2-(2-thienyl)ethyl>piperazin-2-one 

Relevant articles and documents

A Thiophene Analogue of Praziquantel, and Related Systems, by Intramolecular Cyclisation of Acyliminium Salts

N--succinimide (7a) and -glutarimide (7b) on reduction with sodium borohydride in methanol at -10 deg C yield the respective hydroxylactams which on treatment with formic acid cyclise via the intermediate acyliminium ions to 4,5,9,9a-tetrahydropyrrolothienopyridin-7-one (9a) and 4,5,8,9,10,10a-hexahydropyridothienopyridin-7-one (9b) respectively.In a similar manner, 4-cyclohexylcarbonyl-1-piperazine-2,6-dione (11) is converted into the thiophene isostere (2) of praziquantel (1).Likewise, formic acid induced cyclisations of the hydroxylactams derived from N-- (16) and N-succinimide (19) furnish 5,6,10,10a-tetrahydropyrrolothienothiazepin-8(9H)-one (18) and 5,6,10,10a-tetrahydropyrrolothienothiazepin-8(9H)-one (21), respectively.