89508-21-4

Upstream product

• 89508-17-8 4-Benzoyl-6-hydroxy-1-(2-thiophen-2-yl-ethyl)-piperazin-2-one 
• 98-88-4 benzoyl chloride 
• 773011-22-6 1,2,3,6,7,10b-Hexahydro-thieno[3',2':3,4]pyrido[1,2-a]pyrazin-4-one 
• 85567-51-7 2-(thiophene-2-yl)ethyl benzenesulfonate 

Relevant academic research and scientific papers

Synthesis and SAR studies of praziquantel derivatives with activity against Schistosoma japonicum

The synthesis and structure-activity relationship (SAR) studies of praziquantel derivatives with activity against adult Schistosoma japonicum are described. Several of them showed better worm killing activity than praziquantel and could serve as leads for further optimization.

Syntesis of the new tricyclic system thieno pyridopyrazin-4-one

The new tricyclic system thienopyrido(1,2-a)pyrazin-4-one, a thiophenic isostere of the heterocyclic system pyrazino(1,2-a)isoquinolin-4-one is synthesised by cyclization in acidic medium from 4-acyl-6-hydroxy-1-piperazin-