895131-39-2Relevant academic research and scientific papers
Potent and orally efficacious benzothiazole amides as TRPV1 antagonists
Besidski, Yevgeni,Brown, William,Bylund, Johan,Dabrowski, Michael,Dautrey, Sophie,Harter, Magali,Horoszok, Lucy,Hu, Yin,Johnson, Dean,Johnstone, Shawn,Jones, Paul,Leclerc, Sandrine,Kolmodin, Karin,Kers, Inger,Labarre, Maryse,Labrecque, Denis,Laird, Jennifer,Lundstroem, Therese,Martino, John,Maudet, Mickael,Munro, Alexander,Nyloef, Martin,Penwell, Andrea,Rotticci, Didier,Slaitas, Andis,Sundgren-Andersson, Anna,Svensson, Mats,Terp, Gitte,Villanueva, Huascar,Walpole, Christopher,Zemribo, Ronald,Griffin, Andrew M.
, p. 6205 - 6211 (2012/10/29)
Benzothiazole amides were identified as TRPV1 antagonists from high throughput screening using recombinant human TRPV1 receptor and structure-activity relationships were explored to pinpoint key pharmacophore interactions. By increasing aqueous solubility
NEW BENZOTHIAZOLECARBOXAMIDES
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Page/Page column 27-28, (2008/06/13)
The present invention relates to new compounds of formula I, (I) wherein R1 to R4, m, n and p, are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their preparation and to a new intermediate us
