90414-61-2Relevant academic research and scientific papers
Potent and orally efficacious benzothiazole amides as TRPV1 antagonists
Besidski, Yevgeni,Brown, William,Bylund, Johan,Dabrowski, Michael,Dautrey, Sophie,Harter, Magali,Horoszok, Lucy,Hu, Yin,Johnson, Dean,Johnstone, Shawn,Jones, Paul,Leclerc, Sandrine,Kolmodin, Karin,Kers, Inger,Labarre, Maryse,Labrecque, Denis,Laird, Jennifer,Lundstroem, Therese,Martino, John,Maudet, Mickael,Munro, Alexander,Nyloef, Martin,Penwell, Andrea,Rotticci, Didier,Slaitas, Andis,Sundgren-Andersson, Anna,Svensson, Mats,Terp, Gitte,Villanueva, Huascar,Walpole, Christopher,Zemribo, Ronald,Griffin, Andrew M.
, p. 6205 - 6211 (2012)
Benzothiazole amides were identified as TRPV1 antagonists from high throughput screening using recombinant human TRPV1 receptor and structure-activity relationships were explored to pinpoint key pharmacophore interactions. By increasing aqueous solubility
Synthesis of Aryldiazoacetates through Palladium(0)-Catalyzed Deacylative Cross-Coupling of Aryl Iodides with Acyldiazoacetates
Ye, Fei,Wang, Chengpeng,Zhang, Yan,Wang, Jianbo
supporting information, p. 11625 - 11628 (2016/02/19)
Palladium(0)-catalyzed deacylative cross-coupling of aryl iodides and acyldiazocarbonyl compounds can be achieved at room temperature under mild reaction conditions. The coupling reaction represents a highly efficient and general method for the synthesis of aryldiazocarbonyl compounds, which have found wide and increasing applications as precursors for generating donor/acceptor-substituted metallocarbenes.
Delocalized cationic azo dyes containing a thiazole moiety
Salvador, Maria A.,Reis, Lucinda V.,Almeida, Paulo,Santos, Paulo F.
, p. 299 - 303 (2008/09/16)
Several new delocalized cationic azo dyes incorporating a bathochromic thiazole moiety have been prepared in moderate to good yields. The synthesis involved the Knoevenagel condensation of an intermediate azo compound, bearing a terminal formyl group, with methylenic bases generated in situ from benzoazolium and quinolinium salts. All dyes display strong absorption around 700 nm and have shown negative solvatochromic behaviour.
NEW BENZOTHIAZOLECARBOXAMIDES
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Page/Page column 19, (2008/06/13)
The present invention relates to new compounds of formula I, (I) wherein R1 to R4, m, n and p, are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their preparation and to a new intermediate us
