895138-62-2Relevant academic research and scientific papers
Regioselective Synthesis of C3-Hydroxyarylated Pyrazoles
O'Sullivan, Leonie,Patel, Ketul V.,Rowley, Ben C.,Brownsey, Duncan K.,Gorobets, Evgueni,Gelfand, Benjamin S.,Van Humbeck, Jeffrey F.,Derksen, Darren J.
, p. 846 - 854 (2021/12/27)
Pyrazoles are ubiquitous structures in medicinal chemistry. We report the first regioselective route to C3-hydroxyarylated pyrazoles obtained through reaction of pyrazole N-oxides with arynes using mild conditions. Importantly, this method does not requir
Facile synthesis of pyrazoles by iron-catalyzed regioselective cyclization of hydrazone and 1,2-diol under ligand-free conditions
Panda, Niranjan,Ojha, Subhadra
, p. 244 - 251 (2018/03/13)
A facile synthesis of pyrazoles by the cyclization of hydrazones and 1,2-diols was described. In the presence of ferric nitrate, the reaction occurs under neat conditions and makes the use of potassium persulfate to oxidize the diol to α-hydroxy carbaldehyde for the reaction with hydrazones to produce 1,3- and 1,3,5-substituted pyrazoles selectively. The overall regioselective transformation occurs in one-pot under ligand-free, mild conditions even in the presence of air.
Fe-catalyzed one-pot synthesis of 1,3-Di- and 1,3,5-trisubstituted pyrazoles from hydrazones and vicinal diols
Panda, Niranjan,Jena, Ashis Kumar
, p. 9401 - 9406,6 (2012/12/11)
An iron-catalyzed route for the regioselective synthesis of 1,3- and 1,3,5-substituted pyrazoles from the reaction of diarylhydrazones and vicinal diols has been developed. This method was found to be practical with wide substrate scope.
Fe-catalyzed one-pot synthesis of 1,3-Di- and 1,3,5-trisubstituted pyrazoles from hydrazones and vicinal diols
Panda, Niranjan,Jena, Ashis Kumar
, p. 9401 - 9406 (2013/01/15)
An iron-catalyzed route for the regioselective synthesis of 1,3- and 1,3,5-substituted pyrazoles from the reaction of diarylhydrazones and vicinal diols has been developed. This method was found to be practical with wide substrate scope.
