89514-86-3Relevant academic research and scientific papers
Studies on agents with vasodilator and β-blocking activities. II
Seki,Takezaki,Ohuchi,Ohuyabu,Tanimoto,Yamaguchi,Saitoh,Ishimori,Yasuda
, p. 247 - 255 (2007/10/02)
A series of phenoxypropanolamines having a hydrazinopyridazinyl moiety was synthesized. Their hypotensive and β-blocking activities were evaluated after intravenous administration of the compounds to anesthetized rats. Some of them exhibited both activities. In particular, compound 20k is a candidate for clinical use due to its hypotensive activity, equal to that of hydralazine, and its β-blocking activity, 2.7-fold more potent than that of propranolol.
Hydrazinopyridazine compound, process for production thereof, and use thereof as medicament
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, (2008/06/13)
A hydrazinopyridazine compound represented by the formula STR1 wherein R1 represents a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a lower alkyl group which may optionally be substituted by a halogen atom or a hydroxyl, lowe
