53732-26-6

Basic information

• Product Name: 1-(2-Chloro-5-Methylphenoxy)-2,3-epoxypropane
• Synonyms: 1-(2-Chloro-5-Methylphenoxy)-2,3-epoxypropane
• CAS NO: 53732-26-6
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.64614
• Product Categories: Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 53732-26-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Solubility: Chloroform, DCM, Ethyl Acetate, Methanol
• CAS DataBase Reference: 1-(2-Chloro-5-Methylphenoxy)-2,3-epoxypropane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Chloro-5-Methylphenoxy)-2,3-epoxypropane(53732-26-6)
• EPA Substance Registry System: 1-(2-Chloro-5-Methylphenoxy)-2,3-epoxypropane(53732-26-6)

Safety Data

• Hazardous Substances Data: 53732-26-6(Hazardous Substances Data)

Usage

Uses

1-(2-Chloro-5-methylphenoxy)-2,3-epoxypropane is an intermediate in the synthesis of Bupranolol (B689650), an antagonist at the cardiostimulatory low-affinity state of b(1)-adrenoceptors and is known to treat hypertension and tachycardia.

Upstream product

• 615-74-7 2-chloro-5-methylphenol 
• 106-89-8 epichlorohydrin 
• 556-52-5 oxiranyl-methanol 

Downstream Products

• 14556-46-8 bupranolol 
• 15148-80-8 (R)-bupranolol hydrochloride 
• 61877-83-6 (+)-Bupranolol 
• 15148-80-8 (S)-bupranolol hydrochloride 
• 61877-83-6 (-)-Bupranolol 
• 89514-86-3 1-(2-Chloro-5-methylphenoxy)-3-[1,1-dimethyl-3-(3-chloro-6-pyridazinyloxy)propylamino]-2-propanol 
• 89514-71-6 1-(2-Chloro-5-methylphenoxy)-3-[1,1-dimethyl-2-(3-chloro-6-pyridazinylthio)ethylamino]-2-propanol 
• 133154-69-5 6-[3-[2-[3-(2-Chloro-5-methyl-phenoxy)-2-hydroxypropylamino]ethoxy]phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone 
• 133154-59-3 6-[4-[2-[3-(2-Chloro-5-methyl-phenoxy)-2-hydroxypropylamino]ethoxy]phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone 
• 133177-62-5 6-[2-[2-[3-(2-Chloro-5-methyl-phenoxy)-2-hydroxypropylamino]ethyl]benzimidazol-5-yl]-4,5-dihydro-3(2H)-pyridazinone 

Relevant articles and documents

Synthesis, phase behavior and absolute configuration of β-adrenoblocker bupranolol and related compounds

β-Blocker bupranolol 1, it's hydrochloride and their precursors 1-(2-chloro-5-methylphenoxy)-2,3-epoxypropane 2 and 3-(2-chloro-5-methylphenoxy)propane-1,2-diol 3 were prepared in racemic and single-enantiomer forms. For all the studied compounds phase behavior during crystallization was established on the basis of IR, DSC and X-ray investigations. Absolute configurations were established for compounds 1 and 2. Being conglomerate, racemic oxirane 2 was resolved by direct entrainment procedure. Being anticonglomerate, in the process of recrystallization, almost enantiopure 1·HCl accumulates in the mother liquor, not in the crystalline precipitate.

LIGANDS FOR CARDIAC BETA1 ADRENOCEPTOR FOR IMAGING CONGESTIVE HEART FAILURE

Novel β1 adrenoreceptor ligands that find use as imaging agents within nuclear medicine applications (e.g., PET imaging and SPECT imaging) are provided. Methods of imaging, including methods of imaging congestive heart failure, are also provide