89530-05-2Relevant academic research and scientific papers
(Acylaryloxy)acetic Acid Diuretics. 5. acetic Acids
Woltersdorf, O. W.,deSolms, S. J.,Stokker, G. E.,Cragoe, E. J.
, p. 840 - 845 (2007/10/02)
Investigation of the chemistry of the potent uricosuric diuretic indacrinone (MK-196) prompted the synthesis of a series of 3-oxo derivatives, i.e., the indan-1,3-diones.In general, both pharmacological parameters (uricosuria and diuresis) were significantly less pronounced with the 1,3-diones than with the parent 1-oxo compounds
Pharmaceutical compositions and method of treatment employing 1,3-dioxo-2,2-disubstituted indanyloxy alkanoic acids
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, (2008/06/13)
[1,3-Dioxo-2-substituted and 2,2-disubstituted-indanyloxy(or thio)]alkanoic acids and their salts, esters and amides are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. The ac
