895367-63-2Relevant articles and documents
Lanthanide Complexes that Respond to Changes in Cyanide Concentration in Water
Routledge, Jack D.,Zhang, Xuejian,Connolly, Michael,Tropiano, Manuel,Blackburn, Octavia A.,Kenwright, Alan M.,Beer, Paul D.,Aldridge, Simon,Faulkner, Stephen
, (2017)
Cyanide ions are shown to interact with lanthanide complexes of phenacylDO3A derivatives in aqueous solution, giving rise to changes in the luminescence and NMR spectra. These changes are the consequence of cyanohydrin formation, which is favored by the c
Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor
Huynh, Tracey,Valant, Celine,Crosby, Ian T.,Sexton, Patrick M.,Christopoulos, Arthur,Capuano, Ben
, p. 8196 - 8200 (2013/11/06)
The M4 mAChR is implicated in several CNS disorders and possesses an allosteric binding site for which ligands modulating the affinity and/or efficacy of ACh may be exploited for selective receptor targeting. We report the synthesis of a focused library of putative M4 PAMs derived from VU0152100 and VU10005. These compounds investigate the pharmacological effects of previously identified methoxy and fluoro substituents, providing useful estimates of affinity (KB), cooperativity (αβ), and direct agonist properties (τB).