89543-83-9

Upstream product

• 1449782-41-5 butyl 2-(trityloxy)acetate 
• 3536-96-7 vinylmagnesium chloride 
• 76-83-5 trityl chloride 
• 141561-60-6 ((E)-But-2-enyl)-trityl-ether 
• 497-06-3 3,4-butenediol 
• 213681-85-7 (S)-1-(t-butyldiphenylsiloxy)-2-(1,3-dithian-2-yl)propane 

Downstream Products

• 89543-89-5 1-(3-Phenyl-4,5-dihydro-isoxazol-5-yl)-2-trityloxy-ethanol 
• 942056-39-5 1-(triphenyl-λ⁵-phosphoranylidene)-3-(triphenylmethyloxymethylallyloxy)propan-2-one 
• 1206535-36-5 2-bromoacetic acid 1-trityloxymethylallyl ester 
• 1391001-97-0 tert-butyl 2-((1-(trityloxy)but-3-en-2-yl)oxy)acetate 
• 1449782-74-4 diethyl (1Z,3E)-5-(trityloxy)penta-1,3-dienylphosphonate 
• 1388651-54-4 1-morpholino-2-(1-(trityloxy)but-3-en-2-yloxy)ethanone 
• 1388651-15-7 N-((4aS,5S,7aS)-7a-(2,3-difluorophenyl)-5-((trityloxy)methyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)benzamide 
• 1388651-08-8 N-(((3S,4R,5S)-3-(2,3-difluorophenyl)-4-(hydroxymethyl)-5-((trityloxy)methyl)tetrahydrofuran-3-yl)carbamothioyl)benzamide 
• 1388651-58-8 1-(2,3-difluorophenyl)-2-(1-(trityloxy)but-3-en-2-yloxy)ethanone oxime 
• 1388651-55-5 1-(2,3-difluorophenyl)-2-(1-(trityloxy)but-3-en-2-yloxy)ethanone 
• 942056-40-8 1-(triphenyl-λ⁵-phosphoranylidene)but-3-en-2-one 

Relevant academic research and scientific papers

FUSED AMINODIHYDROTHIAZINE DERIVATIVES

The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine; R is monofluoromethyl or difluoromethyl; and pharmaceutically acceptable salts thereof; which compound has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.

Stereoselective synthesis of dienyl phosphonates via extended tethered ring-closing metathesis

Allylphosphonates of allylic alcohols were converted to conjugated dienyl phosphonates in a one-flask reaction, comprising a ring-closing metathesis (RCM), a base-induced ring-opening, and an alkylation. The ring-opening proceeds with very high diastereoselectivity, giving exclusively the (1Z,3E)-configured dienes. Single diastereomers and mixtures of diastereomers can be used as starting materials without noticeable effect on the diastereoselectivity of the sequence.

FUSED AMINODIHYDROTHIAZINE DERIVATIVES

The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine; R is monofluoromethyl or difluoromethyl; and pharmaceutically acceptable salts thereof; which compound has an Αβ production inhibit

A modular approach to aryl-C-ribonucleosides via the allylic substitution and ring-closing metathesis sequence. A stereocontrolled synthesis of all four α-/β- and D-/L-C-nucleoside stereoisomers

Iridium(I)-catalyzed allylation of the enantiopure monoprotected copper(I) alkoxide, generated from (S)-5a, with the enantiopure allylic carbonates (R)-9a,b has been developed as the key step in a new approach to C-nucleoside analogues. The anomeric cente

Synthesis of 3-oxooxa- and 3-oxoazacycloalk-4-enes by ring-closing metathesis. Application to the synthesis of an inhibitor of cathepsin K

3-Oxooxa- and 3-oxoazacycloalk-4-enes were obtained with good yield from 1-(ω-alkenyloxy)- and 1-(ω-alkenylamino)-but-3-en-2-ones by using a ring-closing metathesis. This methodology has been used to synthesize an inhibitor of cathepsin K.

Stereoselective synthesis of (E)- and (Z)-3-hydroxy-2-methyl-1-alkenyl iodides by base-promoted ring-opening of iodomethylated epoxides

Both (E)- and (Z)-3-hydroxy-2-methyl-1-alkenyl iodides were stereoselectively synthesized from iodomethylated epoxides by treatment with sodium hexamethyldisilazane in DMF and with LDA in THF (or lithium 2,2,6,6-tetramethylpiperidide in THF), respectively

Generation of 2-substituted-2-metallo-1,3-dithianes and their coupling with 1,2-disubstituted epoxides at room temperature

2-Substituted-1,3-dithianes were subjected to lithiation by n-BuLi at room temperature and the resulting anions reacted with 1,2-disubstituted epoxides at room temperature, giving the coupling products in satisfactory yield. In addition, a mixed organomet