89548-89-0Relevant academic research and scientific papers
Multicomponent Strecker reaction under high pressure
Matsumoto, Kiyoshi,Kim, Jong Chul,Iida, Hirokazu,Hamana, Hiroshi,Kumamoto, Koji,Kotsuki, Hiyoshizo,Jenner, Gerard
, p. 1734 - 1753 (2005)
For the first time, uncatalyzed, high-pressure (0.6 GPa) reactions with ketones have proven to be a powerful way to perform the three-component Strecker synthesis of α-amino nitriles in high yields. Two types of double Strecker reactions were achieved, but attempts to perform triple Strecker reactions were unsuccessful.
