895536-73-9Relevant academic research and scientific papers
Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP
Roecker, Anthony J.,Coleman, Paul J.,Mercer, Swati P.,Schreier, John D.,Buser, Carolyn A.,Walsh, Eileen S.,Hamilton, Kelly,Lobell, Robert B.,Tao, Weikang,Diehl, Ronald E.,South, Vicki J.,Davide, Joseph P.,Kohl, Nancy E.,Yan, Youwei,Kuo, Lawrence C.,Li, Chunze,Fernandez-Metzler, Carmen,Mahan, Elizabeth A.,Prueksaritanont, Thomayant,Hartman, George D.
, p. 5677 - 5682 (2007)
Inspired by previous efforts in the pyrazolobenzoxazine class of KSP inhibitors, the design and synthesis of 1,4-diaryl-4,5-dihydropyrazole inhibitors of KSP are described. Crystallographic evidence of binding mode and in vivo potency data is also highlig
MITOTIC KINESIN INHIBITORS
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Page/Page column 50, (2008/06/13)
The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to composition
