89562-34-5

Upstream product

• 59157-06-1 4H,9H-diimidazo<1,5-a; 1',5'-d>pyrazine-5,10-dione-1,6-dicarboxylic dichloride 
• 62-53-3 aniline 
• 570-22-9 4,5-imidazoledicarboxylic acid 

Downstream Products

• 124928-16-1 5-[1-(5-Nitro-furan-2-yl)-meth-(E)-ylidene-hydrazinocarbonyl]-1H-imidazole-4-carboxylic acid phenylamide 
• 89562-40-3 5-Hydrazinocarbonyl-1H-imidazole-4-carboxylic acid phenylamide 

Relevant academic research and scientific papers

Synthesis and evaluation of imidazole-4,5-and pyrazine-2,3-dicarboxamides targeting dengue and yellow fever virus

The results of a high-throughput screening assay using the dengue virus-2 replicon showed that the imidazole 4,5-dicarboxamide (I45DC) derivative (15a) has a high dengue virus inhibitory activity. Based on 15a as a lead compound, a novel class of both disubstituted I45DCs and the resembling pyrazine 2,3-dicarboxamides (P23DCs) were synthesized. Here, we report on their in vitro inhibitory activity against dengue virus (DENV) and yellow fever virus (YFV). Some of these first generation compounds have shown activity against both viruses in the micromolar range. Within this series, compound 15b was observed to display the highest antiviral potency against YFV with an EC50 Combining double low line 1.85 μM. In addition, compounds 20a and 20b both potently inhibited replication of DENV (EC50 Combining double low line 0.93 μM) in Vero cells.

Imidazole-4,5-dicarboxamide derivatives with antiproliferative activity against HL-60 cells

A series of N,N′-disubstituted imidazole-4,5-dicarboxamides (I45DCs) were prepared and tested in order to determine their antiproliferative activity against HL-60 cells. The design of the I45DCs was based in part on the structures of trisubstituted purine