570-22-9

Usage

Uses

Used in Research Applications:
4,5-Imidazoledicarboxylic acid is used as a research compound for studying its properties and potential applications in various fields, including medicinal chemistry and drug discovery.
Used in Pharmaceutical Industry:
4,5-Imidazoledicarboxylic acid is used as an intermediate in the synthesis of N-substituted cyclic imides, which possess anticancer and anti-inflammatory activities. This makes it a valuable component in the development of new therapeutic agents for the treatment of cancer and inflammatory disorders.
Used in Medicinal Chemistry:
4,5-Imidazoledicarboxylic acid is also used to prepare imidazolecarboxamide derivatives, which exhibit cannabinoid CB2 receptor antagonistic activities. These derivatives have potential applications in the treatment of various diseases and conditions, such as neurodegenerative disorders, pain management, and metabolic disorders, by modulating the endocannabinoid system.

InChI:InChI=1/C5H4N2O4/c8-4(9)2-3(5(10)11)7-1-6-2/h1H,(H,6,7)(H,8,9)(H,10,11)/p-2

Upstream product

• 51-17-2 benzoimidazole 
• 874000-31-4 1H-cyclohePtimidazol-6-one-imine 
• 50-00-0 formaldehyd 
• 13171-63-6 L_g-tartaric acid-dinitrate 
• 100-97-0 hexamethylenetetramine 
• 1122-28-7 4,5-dicyano-1H-imidazole 
• 125029-70-1 5-Dimethylaminomethylimidazole-4-carboxylic Acid Hydrochloride 
• 288-32-4 1H-imidazole 
• 5465-29-2 2-propyl-1H-benzimidazole 
• 716-79-0 2-phenyl-1H-benzoimidazole 
• 1848-84-6 2-ethylbenzimidazole 
• 615-15-6 2-Methyl-1H-benzimidazole 
• 125029-71-2 2,4,5-Tris(dimethylaminomethyl)imidazole Trihydrochloride 

Downstream Products

• 1080-79-1 imidazole 4,5-dicarboxylic acid diethyl ester 
• 13189-13-4 1⁽³⁾H-imidazole-4-carboxylic acid anilide 
• 19485-38-2 1-methyl-1H-imidazole-4,5-dicarboxylic acid 
• 288-32-4 1H-imidazole 
• 15719-64-9 methylammonium carbonate 
• 125029-70-1 5-Dimethylaminomethylimidazole-4-carboxylic Acid Hydrochloride 
• 1072-84-0 imidazole-4-carboxylic acid 
• 651-34-3 4,5-bis(trifluoromethyl)imidazole 
• 5467-45-8 2-Phenylazo-1H-imidazole-4,5-dicarboxylic acid 
• 26832-08-6 imidazole-4-carboxamide 
• 74-90-8 hydrogen cyanide 
• 59157-06-1 4H,9H-diimidazo<1,5-a; 1',5'-d>pyrazine-5,10-dione-1,6-dicarboxylic dichloride 
• 233584-99-1 4,5-bis{[(1,1-dimethylethoxy)-(S)-phenylalanyl]carbonyl}-1H-imidazole 
• 887423-66-7 [silver(I)(imidazole-4,5-dicarboxylic acid-1H)(triphenylphosphine)2] 

Relevant academic research and scientific papers

Synthesis, structure, and photoluminescent property of a trinuclear Cd II complex based on semi-rigid bis(imidazole-4,5-dicarboxylate) ligand

A new 3D complex, {[Cd3(HL)2(H2L)(H 2O)4]·2H2O}n (1) (H 4L = 1,1′-(1,4-phenylenebis(methylene))bis(1H-imidazole-4,5- dicarboxylic acid), has been hydrothermally synthesized and characterized by elemental analyses, IR, TG, and X-ray single-crystal diffraction. Complex 1 is the first framework based on CdII ion and semi-rigid bis-IDC ligand. The (6,6)-net architecture of 1 is built from H2L2 - ligands linking 1D chain-like [Cd3(HL)2]n SBUs, which formed by HL3 - anions bridging two kinds of metal centers. In addition, complex 1 was demonstrated to display strong blue-violet fluorescence emission in the solid state at room temperature.

Preparation method of nitrogen-containing aromatic dicarboxylic acid

The invention discloses a preparation method of nitrogen-containing aromatic dicarboxylic acid. The method includes: taking quinoline, isoquinoline, benzimidazole or benzotriazole and a derivative thereof as the raw materials, adopting oxone as the oxidant, employing a metal salt as the catalyst and using inorganic acid as the medium, adding a phase transfer reagent, and carrying out reaction to obtain nitrogen-containing aromatic dicarboxylic acid. The reagents used by the method are high in stability, convenient for transportation and storage, the operation is simple, the conditions are easily controllable, and the price is low, at the same time, the catalytic effect is good, the yield is high, and waste liquid treatment is easy, therefore the method is convenient for industrial large-scale production.

Olmesartan high purity intermediate 2-propyl imidazole -4,5-dicarboxylic acid preparation method and application

The invention provides a preparation method of 2-propylimidazolyl-4,5-dicarboxylic acid (1). According to the method, the concentration of the sulfuric acid solution, the volume/mass ratio of the sulfuric acid solution to 2-propyl benzimidazole, the volume ratio of the oxydol to the sulfuric acid water solution, reaction time, added water volume and cooling recrystallization temperature are accurately controlled to obviously lower the content of the impurity imidazolyl-4,5-dicarboxylic acid (8), thereby further obtaining the high-purity olmesartan medoxomil. The invention also provides a compound disclosed as Formula 9 and application thereof in olmesartan medoxomil preparation as a control quality standard substance.

CARBOXYIMIDAZOLES IN THE MANNICH REACTION

Depending on the reagent ratio, 5-dimethylaminomethyl-4-imidazole-4-carboxylic acid ad 2,4,5-tris(dimethylaminomethyl)imidazole were obtained in the aminomethylation of imidazole-4-carboxylic and imidazole-4,5-dicarboxylic acids.The oxidation of these compounds with nitric acid leads to imidazole-4,5-dicarboxylic acid.

Dinuclear Rhodium and Iridium Complexes of Dicarboxyimidazolates; Crystal Structure of *2PriOH

Dinuclear complexes of rhodium and iridium with 4,5-dicarboxyimidazole (H3dcbi) and 4,5-dicarboxy-2-methylimidazole (H3dcbmi) are reported.In each case, the bridging carboxyimidazole ligand binds as the trianion.The auxiliary ligands are cyclo-octa-1,5-diene (cod), carbon monoxide, and triphenylphosphine.The CO complexes, such as which contains a planar dinuclear anion, exhibit strong colours which are caused by intermolecular stacking interactions and which are modulated by the counter cation.The X-ray crystal structure of iOH is described.

Preparation of imidazole-4,5-dicarboxylic acid

Imidazole-4,5-dicarboxylic acid is prepared by a process in which imidazole is reacted with formaldehyde, and the reaction mixture is treated with nitric acid.