89569-19-7Relevant academic research and scientific papers
Synergistic promoting effect of ball milling and KF-alumina support for the green synthesis of benzothiazinones
Sharifi, Ali,Ansari, Mohammad,Darabi, Hossein Reza,Abaee, M. Saeed
, p. 529 - 532 (2016)
A solvent-free procedure was developed for the reaction of 2-aminothiophenols with 2-bromoalkanoates, where KF-Al2O3 support and ball milling cooperatively lead to a green and efficient synthesis of several benzothiazinone derivatives in good to excellent yields. The catalyst could be recycled in further reactions while maintaining its activity.
[NO3], a green and base-free medium for one-pot synthesis of benzothiazinones at room temperature
Sharifi, Ali,Abaee, M. Saeed,Rouzgard, Mahdiyeh,Mirzaei, Mojtaba
, p. 2079 - 2089 (2013/06/26)
A general and efficient room-temperature procedure is developed for high-yield synthesis of 2H-benzo[b][1,4]thiazin-3(4H)-one derivatives in one pot from the reaction of 2-aminothiophenols with 2-bromoalkanoates in ionic liquid [bmim]NO3 without the use of any catalyst, base, or additive. Products were obtained in good yields by simple extraction with Et2O followed by evaporation of the volatile contents and recrystallization from Et2O. The ionic liquid was recycled and reused in the next reaction without the loss of its activity.
Regioselective one pot synthesis of 2-alkyl/aryl-4H-benzo[1,4]thiazine-3- one via microwave irradiation
Kamila, Sukanta,Koh, Benjamin,Khan, Omair,Zhang, Hongming,Biehl, Edward R.
, p. 1641 - 1646 (2007/10/03)
A series of 2-alkyl/aryl-4H-benzo[1,4]thiazine-3-ones have been synthesized by microwave irradiation of ethyl-2-bromo-2-alkyl/aryl acetate and 2-amino thiophenol in the presence of 1,8-diazabicyclo-[5.4.0]undec-7-ene and N-methylpiperidine. All compounds were characterized by 1H NMR, 13C NMR and elemental analyses, and by X-ray crystallography in the case of 2-methyl-4H-benzo[1,4]thiazin-3-one.
