89581-71-5

Usage

Uses

Used in Pharmaceutical Industry:
2-chloro-6-nitrobenzenesulfonamide is used as an intermediate in the synthesis of pharmaceuticals for its ability to inhibit certain enzymes, contributing to the development of drugs with specific therapeutic effects.
Used in Dye Industry:
2-chloro-6-nitrobenzenesulfonamide is used as a precursor in the synthesis of dyes and pigments, playing a crucial role in the production of various colorants for different applications.
Used in Antibacterial Applications:
Due to its antibacterial properties, 2-chloro-6-nitrobenzenesulfonamide is used in the development of antimicrobial agents, helping to combat bacterial infections.
Used in Antifungal Applications:
Leveraging its antifungal properties, 2-chloro-6-nitrobenzenesulfonamide is utilized in the creation of antifungal products, addressing fungal infections and related issues.

Upstream product

• 17970-75-1 2-chloro-6-nitrobenzenesulfonyl chloride 
• 178551-28-5 2-(benzylsulfanyl)-1-chloro-3-nitrobenzene 

Downstream Products

• 89639-40-7 2-amino-6-chlorobenzenesulfonamide 
• 93899-89-9 8-chloro-3-phenethyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 

Relevant academic research and scientific papers

Design, synthesis and herbicidal activity study of aryl 2,6-disubstituted sulfonylureas as potent acetohydroxyacid synthase inhibitors

A series of sulfonylurea derivatives containing a 2,6-disubstituted aryl moiety were designed, synthesized and evaluated for their herbicidal activities. Most of these compounds showed excellent inhibitory rates against both monocotyledonous and dicotyledonous weeds, especially 10a, 10h and 10i. They exhibited equivalent or superior herbicidal efficiency than commercial chlorsulfuron at the dosage of 15?g/ha and the preliminary SAR was summarized. In order to illuminate the molecular mechanism of several potent compounds, their apparent inhibition constant (Kiapp) of Arabidopsis thaliana acetohydroxyacid synthase (AHAS) were determined and the results confirmed that these compounds were all potent AHAS inhibitors. 10i have a Kiapp of 11.5?nM, which is about 4 times as potent as chlorsulfuron (52.4?nM).

Chloro-substituted 3-alkylamino-4h-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel activators: Impact of the position of the chlorine atom on the aromatic ring on activity and tissue selectivity

The synthesis of 5-chloro-, 6-chloro-, and 8-chloro-substituted 3-alkylamino/cycloalkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides is described. Their inhibitory effect on the insulin releasing process and their vasorelaxant activity was compared to that