89586-52-7

Upstream product

• 80336-62-5 2-bromo-1-(5'-bromo-6'-methoxy-2'-naphthyl)-propan-1-one 
• 2700-47-2 6-methoxy-2-propionylnaphthalene 
• 93-04-9 2-Methoxynaphthalene 
• 135-19-3 β-naphthol 

Downstream Products

• 23981-80-8 naproxen 
• 22204-53-1 (2S)-2-(6-methoxy(2-naphthyl))propanoic acid 

Relevant academic research and scientific papers

Synthesis method of D,L-naproxen

The invention provides a synthesis method of D,L-naproxen. The synthesis method is characterized by comprising the step of removing bromine: taking D,L-2-(5-bromo-6-methoxyl-naphthyl)-sodium propionate as a raw material, and taking water and dioxane as solvents, adding a catalyst under alkaline conditions and nitrogen protection, reacting under 80-90 DEG C, filtering after the reaction is completed, and regulating the pH (Potential of hydrogen) of filtrate by acid to obtain a final product, wherein the catalyst is one of tetrakis(triphenylphosphine)palladium or diacetatobis(triphenylphosphine)palladium(II) or palladium chloride taking triphenylphosphine as a ligand. According to the synthesis method, through optimizing the synthesis method of naproxen, the tetrakis(triphenylphosphine)palladium and the diacetatobis(triphenylphosphine) palladium(II) as well as the palladium chloride taking the triphenylphosphine as the ligand are adopted as the catalyst to remove the bromine on a benzene ring; hydrogenation and high pressure are not needed; the reaction is safe and reliable; the yield is high; the synthesis method is suitable for industrial production.