89586-99-2

Upstream product

• 99-90-1 para-bromoacetophenone 
• 95-54-5 1,2-diamino-benzene 
• 766-96-1 4-bromo-1-ethynylbenzene 
• 1516-58-1 o-azidonitrobenzene 
• 39145-59-0 o-phenylenediamine hydrochloride 

Downstream Products

• 1176196-27-2 (2S,4S)-2,4-bis(4-bromophenyl)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine 
• 1176195-99-5 (2S,4R)-2,4-bis(4-bromophenyl)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine 
• 1234803-41-8 2,4-bis(4'-bromophenyl)-2-methyl-1-(2'',3'',5''-tri-O-benzoyl-β-D-ribofuranosyl)-2,3-dihydro-1,5-benzodiazepine 

Relevant academic research and scientific papers

A green and sustainable approach for the synthesis of 1,5-benzodiazepines and spirooxindoles in one-pot using a MIL-101(Cr) metal-organic framework as a reusable catalyst

Metal-organic framework MIL-101(Cr) has been efficiently utilized for the synthesis of biologically relevant heterocycles such as 1,5-benzodiazepines and spirooxindoles in one-pot. MIL-101(Cr) was prepared via a solvothermal method and characterized by FT

Assessment of elementary derivatives of 1,5-benzodiazepine as anticancer agents with synergy potential

Herein, we designed and synthesized 1,5-benzodiazepines as a lead molecule for anticancer activity and as potent synergistic activity with drug Methotrexate. Working under the framework of green chemistry principles, series of 1,5-benzodiazepine derivativ

Method for synthesizing 1,5-benzodiazepine compound

The invention discloses a method for synthesizing a 1,5-benzodiazepine compound. The method specifically comprises the following steps: dissolving a gold catalyst, an additive, alkyne of a formula IIshown in the specification, an o-phenylenediamine derivative of a formula III shown in the specification into an organic solvent, putting the solution into a pressure-resistant reaction tube, performing a stirring reaction for 6-24 hours at 25 DEG C so as to obtain a reaction liquid, and performing aftertreatment on the reaction liquid so as to obtain the 1,5-benzodiazepine compound of a formula IV shown in the specification, wherein the mass ratio of the gold catalyst of a formula I shown in the specification to the additive to the alkyne of the formula II shown in the specification to the o-phenylenediamine derivative of the formula III shown in the specification is (0.01-0.07):(0-0.1):(2.0-3.0):1. By adopting the method disclosed by the invention, a double-functional catalyst is used, the reaction can be performed under a room temperature condition, and thus energy consumption can be reduced; and the method has the advantages of being small in catalyst amount, high in yield, good insubstrate universality, simple and convenient in operation, and the like.

Graphite oxide: A metal free highly efficient carbocatalyst for the synthesis of 1,5-benzodiazepines under room temperature and solvent free heating conditions

Graphite Oxide (GO), an attractive metal free carbocatalyst, was employed as a green and highly efficient catalytic system for the synthesis of 1,5-benzodiazepines. The reaction was studied at room temperature as well as at 80°C under solvent free heating

Asymmetric Hydrogenation of Cyclic Imines of Benzoazepines and Benzodiazepines with Chiral, Cationic Ruthenium–Diamine Catalysts

A method for the highly enantioselective hydrogenation of diverse seven-membered N-containing heterocycles, including 2,4-diaryl-3H-benzo[b]azepines, racemic 2,2,4-trisubstituted 2,3-dihydrobenzo[b][1,4]diazepines, and 4-substituted 1H-benzo[b][1,4]diazep

Microwave-Assisted, solvent free preparation of 1,5-benzodiazepine derivatives using nanomagnetic-supported sulfonic acid as a recyclable and heterogeneous catalyst

A new preparation of 1,5-benzodiazepine derivatives has been achieved in good to excellent yields by the condensation of o-phenylenediamine with a variety of ketones employing nano-Fe2O3-SO3H as catalyst under microwave irradiation and solvent-free condit

An efficient facile and one-pot synthesis of benzodiazepines and chemoselective 1,2-disubstituted benzimidazoles using a magnetically retrievable Fe3O4 nanocatalyst under solvent free conditions

Benzodiazepine and chemoselective 1,2-disubstituted benzimidazole derivatives were synthesized by the condensation reaction of o-phenylenediamine with ketones and aryl aldehydes using Fe3O4 nanoparticles as a recyclable catalyst unde

Synergistic catalysis by an aerogel supported ionic liquid phase (ASILP) in the synthesis of 1,5-benzodiazepines

An ionic liquid film of [Bmim]Cl containing an organometallic catalyst (Cp2ZrCl2) has been anchored on the porous matrix of an aerogel by adsorption interactions. The synthesized aerogel supported ionic liquid phase catalyst was succ

Gold(I)-catalyzed synthesis of 1,5-benzodiazepines directly from o-phenylenediamines and alkynes

A unique gold(I)-catalyzed highly atom-economic synthesis of 1,5-benzodiazepines directly from o-phenylenediamines and alkynes has been achieved for the first time.

Terminal alkynes as keto-methyl equivalent toward one pot synthesis of 1,5-benzodiazepine derivatives under catalysis of Hg(OTf)2

Mercuric triflate catalyzes the reaction between 1,2-diaminobenzene and terminal alkynes to afford 2,4-disubstituted 2-methyl-2,3-dihydro-1H-benzo[b][1, 4]diazepine in an excellent yield. The terminal alkynes function as a source of keto-methyl equivalent.