89586-99-2

Basic information

• Product Name: 1H-1,5-Benzodiazepine, 2,4-bis(4-bromophenyl)-2,3-dihydro-2-methyl-
• CAS NO: 89586-99-2
• Molecular Formula: C22H18Br2N2
• Molecular Weight: 470.206
• Mol File: 89586-99-2.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 1H-1,5-Benzodiazepine, 2,4-bis(4-bromophenyl)-2,3-dihydro-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,5-Benzodiazepine, 2,4-bis(4-bromophenyl)-2,3-dihydro-2-methyl-(89586-99-2)
• EPA Substance Registry System: 1H-1,5-Benzodiazepine, 2,4-bis(4-bromophenyl)-2,3-dihydro-2-methyl-(89586-99-2)

Safety Data

• Hazardous Substances Data: 89586-99-2(Hazardous Substances Data)

Upstream product

• 766-96-1 4-bromo-1-ethynylbenzene 
• 95-54-5 1,2-diamino-benzene 
• 99-90-1 para-bromoacetophenone 
• 1516-58-1 o-azidonitrobenzene 
• 39145-59-0 o-phenylenediamine hydrochloride 

Downstream Products

• 1176196-27-2 (2S,4S)-2,4-bis(4-bromophenyl)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine 
• 1176195-99-5 (2S,4R)-2,4-bis(4-bromophenyl)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine 
• 1234803-41-8 2,4-bis(4'-bromophenyl)-2-methyl-1-(2'',3'',5''-tri-O-benzoyl-β-D-ribofuranosyl)-2,3-dihydro-1,5-benzodiazepine 

Relevant articles and documents

A green and sustainable approach for the synthesis of 1,5-benzodiazepines and spirooxindoles in one-pot using a MIL-101(Cr) metal-organic framework as a reusable catalyst

Metal-organic framework MIL-101(Cr) has been efficiently utilized for the synthesis of biologically relevant heterocycles such as 1,5-benzodiazepines and spirooxindoles in one-pot. MIL-101(Cr) was prepared via a solvothermal method and characterized by FT

Method for synthesizing 1,5-benzodiazepine compound

The invention discloses a method for synthesizing a 1,5-benzodiazepine compound. The method specifically comprises the following steps: dissolving a gold catalyst, an additive, alkyne of a formula IIshown in the specification, an o-phenylenediamine derivative of a formula III shown in the specification into an organic solvent, putting the solution into a pressure-resistant reaction tube, performing a stirring reaction for 6-24 hours at 25 DEG C so as to obtain a reaction liquid, and performing aftertreatment on the reaction liquid so as to obtain the 1,5-benzodiazepine compound of a formula IV shown in the specification, wherein the mass ratio of the gold catalyst of a formula I shown in the specification to the additive to the alkyne of the formula II shown in the specification to the o-phenylenediamine derivative of the formula III shown in the specification is (0.01-0.07):(0-0.1):(2.0-3.0):1. By adopting the method disclosed by the invention, a double-functional catalyst is used, the reaction can be performed under a room temperature condition, and thus energy consumption can be reduced; and the method has the advantages of being small in catalyst amount, high in yield, good insubstrate universality, simple and convenient in operation, and the like.

Asymmetric Hydrogenation of Cyclic Imines of Benzoazepines and Benzodiazepines with Chiral, Cationic Ruthenium–Diamine Catalysts

A method for the highly enantioselective hydrogenation of diverse seven-membered N-containing heterocycles, including 2,4-diaryl-3H-benzo[b]azepines, racemic 2,2,4-trisubstituted 2,3-dihydrobenzo[b][1,4]diazepines, and 4-substituted 1H-benzo[b][1,4]diazep