89593-76-0

Basic information

• Product Name: Benzoic acid, 4-(4,5-dichloro-6-oxo-1(6H)-pyridazinyl)-, ethyl ester
• CAS NO: 89593-76-0
• Molecular Formula: C13H10Cl2N2O3
• Molecular Weight: 313.14
• Mol File: 89593-76-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-(4,5-dichloro-6-oxo-1(6H)-pyridazinyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(4,5-dichloro-6-oxo-1(6H)-pyridazinyl)-, ethyl ester(89593-76-0)
• EPA Substance Registry System: Benzoic acid, 4-(4,5-dichloro-6-oxo-1(6H)-pyridazinyl)-, ethyl ester(89593-76-0)

Safety Data

• Hazardous Substances Data: 89593-76-0(Hazardous Substances Data)

Upstream product

• 766-40-5 Mucochloric acid 
• 14685-90-6 4-ethoxycarbonylphenylhydrazine 

Downstream Products

• 1415356-11-4 C₂₀H₁₇ClN₂O₅ 

Relevant articles and documents

Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)

Novel small molecule antagonists of NPBWR1 (GPR7) are herein reported. A high-throughput screening (HTS) of the Molecular Libraries-Small Molecule Repository library identified 5-chloro-4-(4-methoxyphenoxy)-2-(p-tolyl) pyridazin-3(2H)-one as a NPBWR1 hit antagonist with micromolar activity. Design, synthesis and structure-activity relationships study of the HTS-derived hit led to the identification of 5-chloro-2-(3,5-dimethylphenyl)-4-(4-methoxyphenoxy) pyridazin-3(2H)-one lead molecule with submicromolar antagonist activity at the target receptor and high selectivity against a panel of therapeutically relevant off-target proteins. This lead molecule may provide a pharmacological tool to clarify the molecular basis of the in vivo physiological function and therapeutic utility of NPBWR1 in diverse disease areas including inflammatory pain and eating disorders.