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CAS

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89597-80-8

Urea, N-(5-benzoyl-1H-benzimidazol-2-yl)-N'-(2-hydroxyethyl)-, also known as albiglutide, is a complex chemical compound belonging to the class of benzimidazoles. It is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist, which is used in the treatment of type 2 diabetes. Albiglutide is a fusion protein consisting of a modified human GLP-1 molecule and human albumin, designed to extend the duration of action and improve the pharmacokinetic profile. This allows for less frequent dosing and better glycemic control in patients with type 2 diabetes. The chemical structure of albiglutide features a urea linkage between the benzimidazole moiety and the hydroxyethyl group, which contributes to its stability and pharmacological properties.

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  • 89597-80-8 Structure

  • Basic information

    1. Product Name: Urea, N-(5-benzoyl-1H-benzimidazol-2-yl)-N'-(2-hydroxyethyl)-
    2. Synonyms:
    3. CAS NO:89597-80-8
    4. Molecular Formula: C17H16N4O3
    5. Molecular Weight: 324.339
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 89597-80-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Urea, N-(5-benzoyl-1H-benzimidazol-2-yl)-N'-(2-hydroxyethyl)-(CAS DataBase Reference)
    10. NIST Chemistry Reference: Urea, N-(5-benzoyl-1H-benzimidazol-2-yl)-N'-(2-hydroxyethyl)-(89597-80-8)
    11. EPA Substance Registry System: Urea, N-(5-benzoyl-1H-benzimidazol-2-yl)-N'-(2-hydroxyethyl)-(89597-80-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 89597-80-8(Hazardous Substances Data)

89597-80-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 89597-80-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,5,9 and 7 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 89597-80:
(7*8)+(6*9)+(5*5)+(4*9)+(3*7)+(2*8)+(1*0)=208
208 % 10 = 8
So 89597-80-8 is a valid CAS Registry Number.

89597-80-8Downstream Products

89597-80-8Relevant articles and documents

Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1

Zhang, Zhongsheng,Ojo, Kayode K.,Johnson, Steven M.,Larson, Eric T.,He, Penqing,Geiger, Jennifer A.,Castellanos-Gonzalez, Alejandro,White Jr., A. Clinton,Parsons, Marilyn,Merritt, Ethan A.,Maly, Dustin J.,Verlinde, Christophe L.M.J.,Van Voorhis, Wesley C.,Fan, Erkang

scheme or table, p. 5264 - 5267 (2012/09/07)

Calcium-dependent protein kinase-1 (CDPK1) from Cryptosporidium parvum (CpCDPK1) and Toxoplasma gondii (TgCDPK1) have become attractive targets for discovering selective inhibitors to combat infections caused by these protozoa. We used structure-based design to improve a series of benzoylbenzimidazole-based compounds in terms of solubility, selectivity, and potency against CpCDPK1 and TgCDPK1. The best inhibitors show inhibitory potencies below 50 nM and selectivity well above 200-fold over two human kinases with small gatekeeper residues.

Synthesis of potential antifilarial agents. 1. 1-(5-Benzoylbenzimidazol-2-yl)-3-alkyl- and -arylureas

Ram,Skinner,Kalvin,Wise,Townsend,McCall,Worth,Ortwine,Werbel

, p. 914 - 917 (2007/10/02)

A series of 1-(5-benzoylbenzimidazol-2-yl)-3-substituted ureas has been synthesized by reacting an appropriate isocyanate with 2-amino-5-benzoylbenzimidazole or by reacting methyl (5-benzoylbenzimidazol-2-yl)carbamate with various amines. Several of the c

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