896106-16-4

Basic information

• Product Name: IMiquiMod (Maleate)
• Synonyms: IMiquiMod (Maleate)
• CAS NO: 896106-16-4
• Molecular Formula: C18H20N4O4
• Molecular Weight: 356.3758
• Mol File: 896106-16-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: IMiquiMod (Maleate)(CAS DataBase Reference)
• NIST Chemistry Reference: IMiquiMod (Maleate)(896106-16-4)
• EPA Substance Registry System: IMiquiMod (Maleate)(896106-16-4)

Safety Data

• Hazardous Substances Data: 896106-16-4(Hazardous Substances Data)

Upstream product

• 110-17-8 (2E)-but-2-enedioic acid 
• 99011-02-6 imiqimod 
• 110-16-7 maleic acid 

Relevant articles and documents

A PROCESS FOR THE PREPARATION OF SUBSTANTIALLY PURE 4-AMINO-1-ISOBUTYL-1H-IMIDAZO[4,5-C]-QUINOLINE (IMIQUIMOD)

A process for preparation of Imiquimod comprising oxidation of 1-Isobutyl-1H-imidazo-[4,5-c]-quinoline (II) afforded 1-Isobutyl-1H- imidazo-[4,5-c]-quinoline-5-N-oxide(III) which is isolated in pure form as its hydrochloride salt (IV) followed by conversion to 4-chloro derivative(V) and conversion to corresponding 4-iodo derivative (VI) which is a novel intermediate. This novel intermediate is converted to imiquimod (VIII) and purified via its organic salt. The invention also relates to crystalline polymorphic forms of Imiquimod Maleate, Fumarate and Oxalate.