896139-85-8

Basic information

• Product Name: Imidazo[1,2-a]pyridin-7-ol
• Synonyms: 7-Hydroxyimidazo[1,2-a]pyridine;Imidazo[1,2-a]pyridin-7-ol;Imidazo[1,2-a]pyridin-7-ol 896139-85-8
• CAS NO: 896139-85-8
• Molecular Formula: C₇H₆N₂O
• Molecular Weight: 134.13534
• Product Categories: Heterocycles;Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 896139-85-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.33±0.1 g/cm3 (20 ºC 760 Torr)
• Refractive Index: 1.668
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO, Methanol
• PKA: 2.96±0.53(Predicted)
• CAS DataBase Reference: Imidazo[1,2-a]pyridin-7-ol(CAS DataBase Reference)
• NIST Chemistry Reference: Imidazo[1,2-a]pyridin-7-ol(896139-85-8)
• EPA Substance Registry System: Imidazo[1,2-a]pyridin-7-ol(896139-85-8)

Safety Data

• Hazardous Substances Data: 896139-85-8(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

Intermediate for heterocyclic compounds as tyrosine kinase inhibitors and anticancer agents

InChI:InChI=1/C7H6N2O/c10-6-1-3-9-4-2-8-7(9)5-6/h1-5,10H

Upstream product

• 107-20-0 2-chloroethanal 
• 33631-05-9 2-amino-4-hydroxypyridine 
• 4532-25-6 7-chloroimidazo-[1,2-a]pyridine 
• 808744-34-5 7-bromoimidazo[1,2-a]pyridine 

Downstream Products

• 1251863-67-8 C₂₆H₃₁F₃N₄O₅ 
• 1251863-09-8 1-{3-[7-(2-Hydroxy-ethoxy)-imidazo[1,2-a]pyridin-3-yl]-5-isopropoxy-phenyl}-3-(2,2,2-trifluoro-ethyl)-urea 

Relevant articles and documents

ErbB RECEPTOR INHIBITORS AS ANTI-TUMOR AGENTS

Provided herein are novel compounds as inhibitors of type I receptor tyrosine kinases, the pharmaceutical compositions comprising one or more of the compounds and salts thereof as an active ingredient, and the use of the compounds and salts thereof in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals and especially in humans.

Imidazo[1,2-a]pyridine compound, and preparation method and applications thereof

The invention discloses an imidazo[1,2-a]pyridine compound, and a preparation method and applications thereof. The imidazo[1,2-a]pyridine compound can inhibit the activity of NEK2 kinases as an NEK2 micro-molecular inhibitor with a novel structure. The in