89615-73-6

Basic information

• Product Name: (R)-2-Acetamido-3-(4-nitrophenyl)propanoic acid
• Synonyms: (R)-2-acetamido-3-(4-nitrophenyl)propanoic acid;N-acetyl-4-nitro- D-Phenylalanine
• CAS NO: 89615-73-6
• Molecular Formula: C₁₁H₁₂N₂O₅
• Molecular Weight: 252.22
• Product Categories: API intermediates
• Mol File: 89615-73-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 554.7 °C at 760 mmHg
• Flash Point: 289.3 °C
• Appearance: /
• Density: 1.366 g/cm³
• Vapor Pressure: 3.86E-13mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-2-Acetamido-3-(4-nitrophenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-Acetamido-3-(4-nitrophenyl)propanoic acid(89615-73-6)
• EPA Substance Registry System: (R)-2-Acetamido-3-(4-nitrophenyl)propanoic acid(89615-73-6)

Safety Data

• Hazardous Substances Data: 89615-73-6(Hazardous Substances Data)

Usage

General Description

(R)-2-Acetamido-3-(4-nitrophenyl)propanoic acid is a chemical compound that belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is an analog of the widely used pain reliever ibuprofen, and it exhibits similar anti-inflammatory, analgesic, and antipyretic properties. The presence of a nitro group in the phenyl ring of the molecule enhances its ability to inhibit the production of inflammatory mediators, making it a potentially useful drug for treating conditions such as arthritis, fever, and pain. Additionally, the acetamido group in the molecule contributes to its ability to inhibit the action of cyclooxygenase enzymes, which are involved in the production of prostaglandins that contribute to inflammation and pain. Thus, (R)-2-Acetamido-3-(4-nitrophenyl)propanoic acid has the potential to be a valuable therapeutic agent for managing various inflammatory and painful conditions.

InChI:InChI=1/C11H12N2O5/c1-7(14)12-10(11(15)16)6-8-2-4-9(5-3-8)13(17)18/h2-5,10H,6H2,1H3,(H,12,14)(H,15,16)/t10-/m1/s1

Upstream product

• 1991-83-9 4-nitrophenylalanine 
• 62561-97-1 N-acetyl-4-nitro-DL-phenylalanine 
• 3235-26-5 2-(N-acetylamino)-2-benzylpropanedioic diethyl ester 
• 6265-87-8 2-acetylamino-2-(4-nitrobenzyl)malonic acid diethyl ester 
• 93341-45-8 α-acetylamino-4-nitro-trans-cinnamic acid 

Downstream Products

• 56613-61-7 (R)-4-nitro-phenylalanine 
• 127641-82-1 4-nitro-D-phenylalanine ethyl ester; hydrochloride 
• 36097-40-2 N-acetyl-4-nitro-D-phenylalanine ethyl ester 
• 14504-87-1 Ac-p-NO2-D-Phe-Mel-OEt 

Relevant articles and documents

Efficient kinetic resolution of amino acids catalyzed by lipase AS 'Amano' via cleavage of an amide bond

Herein the efficient kinetic resolution of non-natural alpha-amino acids catalyzed by lipase AS 'Amano' via cleaving the amide bond is reported. The starting materials were the corresponding amino acid amides and the amino acids were generated with ees of up to 99% with E values of >600. These results indicated that the lipase AS 'Amano' could be a powerful amide hydrolase for the kinetic resolution of amino acid starting from the corresponding amino acid amides.

Novel spiro phosphinite ligands and their application homogeneous catalytic hydrogenation reactions

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