89622-54-8

Upstream product

• 238096-55-4 N-(2-((1-trimethylsilyl)oxy)pyrimidin-4-yl)benzamide 
• 7355-18-2 (2S,3S,4S,5R,6S)-3,4,5,6-Tetraacetoxy-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 26661-13-2 4-N-benzoylcytosine 
• 98-88-4 benzoyl chloride 

Downstream Products

• 59862-05-4 cytosylglucuronic acid 

Relevant academic research and scientific papers

SYNTHESIS OF DERIVATIVES OF PENTOPYRANIC ACID

N4-Benzoylcytosine 1-(methyl 2,3,4-tri-O-acetyl-β-D-glucopyranosiduronate) has been obtained with a yield of 70percent by the glycosylation of the trimethylsilyl derivative of N4-benzoylcytosine with methyl 1,2,3,4-tetra-O-acetyl-β-D

A mechanistic study of the non-oxidative decarboxylation catalyzed by the radical S-adenosyl-l-methionine enzyme BlsE involved in blasticidin S biosynthesis

Decarboxylation is a fundamentally important reaction in biology and involves highly diverse mechanisms. Here we report a mechanistic study of the non-oxidative decarboxylation catalyzed by BlsE, a radical S-adenosyl-l-methionine (SAM) enzyme involved in blasticidin S biosynthesis. Through a series of biochemical analysis with isotopically labeled reagents, we show that the BlsE-catalyzed reaction is initiated by the 5′-deoxyadenosyl (dAdo) radical-mediated hydrogen abstraction from a sugar carbon of the substrate cytosylglucuronic acid (CGA), and does not involve a carboxyl radical as has been proposed for 4-hydroxyphenylacetate decarboxylase (HPAD). Our study reveals that BlsE represents a mechanistically new type of radical-based decarboxylase.