89635-79-0

Usage

Functional groups

Propyne, three ethoxy groups, one methoxy group

Physical state

Liquid

Uses

Solvent, precursor in the synthesis of other chemical compounds

Safety precautions

Handle with caution, follow appropriate safety protocols due to potential hazardous properties.

Upstream product

• 54149-17-6 2-bromoethyl 2-methoxyethyl ether 
• 107-19-7 propargyl alcohol 
• 111-77-3 2-(2-methoxyethoxy)ethyl alcohol 
• 106-96-7 propargyl bromide 

Downstream Products

• 1293914-53-0 2-((4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chloro benzyl)-5-(3-(2-(2-methoxyethoxy)ethoxy)prop-1-yn-1-yl)quinazolin-4(3H)-one 

Relevant academic research and scientific papers

Pyrene-containing dyes: Reversible click/declick reaction, optical and aggregation behaviors

Pyrene-based dyes were synthesized by a clean, efficient Diels-Alder [4 + 2] click reaction where no catalyst adding or side reactions occurring. The optical behaviors, optoelectronic properties and supramolecular donor/acceptor dipolar interactions of these new dyes were investigated by UV–vis absorption, fluorescence spectroscopy, electrostatic potential and frontier molecular orbital calculations as well as electrochemical cyclic voltammetry measurements. Two pyrene-based dyes can be mutually transformed by reversible formation or cleavage of Diels-Alder covalent bonds through click/declick reaction. During the reversible reaction, switchable fluorescence ON/OFF behaviors were interestingly observed. X-ray single crystal diffraction revealed that supramolecular donor/acceptor dipolar and π-π stacking interactions work cooperatively to form stronger interaction and the shorter distance (3.38 ?) between donor and acceptor than general π-π stacking distance (3.54 ?). An amphiphilic dye is self-assembled in water into blue fluorescent, hollow vesicular aggregates with the average diameter of 115–120 nm and a narrow size distribution as revealed by dynamic light scattering, scanning electron microscopy and transmission electron microscopy.

Azaphilones as Activation-Free Primary-Amine-Specific Bioconjugation Reagents for Peptides, Proteins and Lipids

Residue-selective bioconjugation methods for biomolecules are highly sought to expand the scope of their biological and medical applications. Inspired by the mechanism of the generation of natural vinylogous γ-pyridones (vPDNs), we have developed a novel

NEUROACTIVE STEROIDS AND COMPOSITIONS AND METHODS THEREOF

The invention provides novel neuroactive steroids and pharmaceutical compositions thereof, as well as methods of their preparation and use, in therapy of various diseases and conditions, for example, various neurological or brain diseases.

Coupling reagent with azaphenanthrone structure and application of coupling reagent in preparation of polypeptide and protein conjugate

The invention belongs to the technical field of organic synthesis and protein modification, and particularly relates to a coupling reagent with an azaphenanthrone structure and application of the coupling reagent in preparation of polypeptide and protein conjugage. The polypeptide and protein coupling reagent with the azaphenanthrone structure is good in stability in an aqueous solution, and protein modification operation is simple and convenient. The coupling reagent is novel in structure and different from existing known modification reagents in structure, the coupling product is good in connection stability, and a new technology and a new mode are provided for various functional modifications of polypeptides and proteins.

Synthesis of Pd Complexes Containing Tailed NHC Ligands and Their Use in a Semicontinuous Membrane-Assisted Suzuki Cross-Coupling Process

Homogeneous catalysis has proved to be a reliable method for preparing numerous molecular entities, but catalysts can be expensive and difficult to remove. Because of this, industry targets catalysts that are easily separated and recovered and feature increased turnover numbers. The ongoing shift from multipurpose batch reactors toward continuous manufacturing in fine chemicals synthesis results in a new set of catalyst requirements. This paper reports the design and use of Pd complexes suitable for a semicontinuous Suzuki cross-coupling reaction based on a membrane-assisted reactor. These Pd complexes contain tailed N-heterocyclic carbene (NHC) ligands, allowing internal catalyst recovery by organic solvent nanofiltration with top-layer-modified ceramic membranes. These membranes give selective nanofiltration of the catalyst based on a combination of size exclusion and affinity separation (solvent-solute-membrane interactions). The semicontinuous system developed led to significantly improved turnover numbers, simplified product isolation, and consequently reduced mass intensity by simply adding more of the reactants and reagents to the reaction vessel.

Towards multivalent CD1d ligands: Synthesis and biological activity of homodimeric α-galactosyl ceramide analogues

A library of dimeric CD1d ligands, containing two α-galactosyl ceramide (α-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6″-azido-6″-deoxy- α-galactosyl ceramide derivative and various diynes. Each α-GalCer dimer was tested for its ability to stimulate iNKT cells.

Polyethylene glycol-based homologated ligands for nicotinic acetylcholine receptors

A homologous series of polyethylene glycol (PEG) monomethyl ethers were conjugated with three ligand series for nicotinic acetylcholine receptors. Conjugates of acetylaminocholine, the cyclic analog 1-acetyl-4,4-dimethylpiperazinium, and pyridyl ether A-84543 were prepared. Each series was found to retain significant affinity at nicotinic receptors in rat cerebral cortex with tethers of up to six PEG units. Such compounds are hydrophilic ligands which may serve as models for fluorescent/affinity probes and multivalent ligands for nAChR.