89642-18-2

Usage

Appearance

Yellow solid

Melting point

76-79 °C

Uses

a. Intermediate in the synthesis of pharmaceuticals
b. Intermediate in the synthesis of agrochemicals
c. Intermediate in the synthesis of dyes
d. Production of organic compounds
e. Reagent in chemical reactions

Hazardous properties

a. Potential for skin and eye irritation
b. Respiratory problems if inhaled

Safety precautions

Handle with care due to hazardous nature

Upstream product

• 827-24-7 2-bromo-4-methyl-6-nitroaniline 
• 89-62-3 4-methyl-2-nitroaniline 

Downstream Products

• 1263377-15-6 3-bromo-2-chloro-5-methylaniline 

Relevant academic research and scientific papers

3-SUBSTITUTED PHENYLAMIDINE COMPOUNDS, PREPARATION AND USE THEREOF

The present invention disclosed 3-substituted phenylamidine compounds of general formula (I), wherein R1, R2, R3, R4, R4a, R4b, A and E have the same meanings as defined in description. The

Design, synthesis and structure–activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands

A new series of carboxyaryl-substituted phenylalanines was designed, synthesized and pharmacologically characterized in vitro at native rat ionotropic glutamate receptors as well as at cloned homomeric kainate receptors GluK1–GluK3. Among them, six compounds bound to GluK1 receptor subtypes with reasonable affinity (Kivalues in the range of 4.9–7.5?μM). A structure–activity relationship (SAR) for the obtained series, focused mainly on the pharmacological effect of structural modifications in the 4- and 5-position of the phenylalanine ring, was established. To illustrate the results, molecular docking of the synthesized series to the X-ray structure of GluK1 ligand binding core was performed. The influence of individual substituents at the phenylalanine ring for both the affinity and selectivity at AMPA, GluK1 and GluK3 receptors was analyzed, giving directions for future studies.