89650-54-4Relevant academic research and scientific papers
On the Electron Impact Induced Hydroxyl Loss from o-Nitrostyrene
Depke, Gisbert,Klose, Walter,Schwarz, Helmut,Blum, Wolfgang,Richter, Wilhelm J.
, p. 568 - 571 (1983)
Unimolecular hydroxyl (OD.) loss form regio- and stereo-specifically labelled o-nitrostyrenes 1a, 1c and 1d results in the formation of an ion which upon collisional activation gives identical mass spectra.Suggestions are made which aim at explaining: (i) the loss of stereochemical integrity of the diastereotopic methylene hydrogens in the course of hydroxyl elimination; and (ii) to account for the collision induced losses of CO and HCN from the (1+) ion.
Indole synthesis based on a modified koser reagent
Fra, Laura,Millán, Alba,Souto, José A.,Mu?iz, Kilian
supporting information, p. 7349 - 7353 (2014/07/21)
A new metal-free method for the rapid and productive preparation of indoles has been developed. This process is based on sterically congested hypervalent iodine compounds of the family of Koser reagents, and iodosobenzene in combination with 2,4,5-tris-isopropylbenzene sulfonic acid provides the highest yields and fastest reaction times. This reagent alone promotes the chemoselective oxidative cyclization of 2-amino styrenes to indoles in high yields under mild conditions. Convenient route to indole: A fast, productive, and operationally simple indole synthesis was developed.
