89743-87-3Relevant articles and documents
The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5- a]pyridin-6-yl)amino]-9-(tetrahydro-2 H-pyran-4-yl)-7,9-dihydro-8 H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor
Goldberg, Frederick W.,Finlay, M. Raymond V.,Ting, Attilla K. T.,Beattie, David,Lamont, Gillian M.,Fallan, Charlene,Wrigley, Gail L.,Schimpl, Marianne,Howard, Martin R.,Williamson, Beth,Vazquez-Chantada, Mercedes,Barratt, Derek G.,Davies, Barry R.,Cadogan, Elaine B.,Ramos-Montoya, Antonio,Dean, Emma
, p. 3461 - 3471 (2020/02/04)
DNA-PK is a key component within the DNA damage response, as it is responsible for recognizing and repairing double-strand DNA breaks (DSBs) via non-homologous end joining. Historically it has been challenging to identify inhibitors of the DNA-PK catalyti
Compounds with antiulcer and antisecretory activity. III. N-substituted imidazolones condensed with nitrogen-containing heteroaromatic rings
Bianchi,Butti,Rossi,et al.
, p. 501 - 506 (2007/10/02)
The syntheses of imidazo[4,5-b]pyridin-2-ones and -thiones, imidazo [4,5-c]pyridin-2-ones and 7,9-dihydro-8H-purin-8-ones arylated (or heteroarylated) at an imidazolone nitrogen are reported. Only some compounds of the first series have marked antisecreto
