89667-39-0

Upstream product

• 126565-31-9 (Z)-7-phenyl-7-(3-pyridyl)-6-heptenoate ethyl ester 
• 5424-19-1 3-Benzoylpyridine 
• 50889-29-7 (5-carboxypentyl)triphenylphosphonium bromide 
• 4547-43-7 methyl 6-hydroxycaproate 
• 6654-36-0 methyl 6-oxohexanoate 
• 89668-29-1 (Z)-methyl 7-phenyl-7-(pyridin-3-yl)hept-6-enoate 
• 1338382-16-3 methyl (Z)-7-bromo-7-phenylhept-6-enoate 
• 1338382-15-2 methyl 7,7-dibromohept-6-enoate 
• 502-44-3 hexahydro-2H-oxepin-2-one 

Downstream Products

• 126565-31-9 (Z)-7-phenyl-7-(3-pyridyl)-6-heptenoate ethyl ester 
• 93944-00-4 ethyl (E)-7-(3-pyridyl)-7-phenylhept-6-enoate 

Relevant academic research and scientific papers

The synthesis of stereodefined trisubstituted olefins from olefin templates using Pd catalysis-synthesis of the antihypertensive isbogrel

A collection of highly functionalized, trisubstituted olefin building blocks (templates) have been developed for their Pd-catalyzed elaboration into more complex structures, including natural products and compounds of medicinal chemistry interest. The Pd-mediated transformations involve a combination of allylic substitution and cross-coupling reactions. The templates have been designed such that these processes proceed not only with a high degree of regio-and stereoselectivity, but the transformations can all be conducted sequentially in the same flask using the same catalyst. A strategy has been devised whereby small, highly functionalized olefin building blocks are systematically converted to a variety of products using the same catalyst.

N-HYDROXYUREA DERIVATIVES

An N-hydroxyurea derivative or a pharmacologically acceptable salt thereof having the formula (I): wherein, A represents CH, CH-CH2, CH-O, or C=CH, X represents O or S, B represents a C1to C8alkylene, C2to C6alkenylene, m-phenylene, or p-phenylene, R represents a hydrogen atom, halogen atom, C1to C4alkyl which may be substituted with a halogen atom, C1to C4alkoxy which may be substituted with a halogen atom, or nitro, R1represents a hydrogen atom, C1to C4lower alkyl, or phenyl, and R2represents a hydrogen atom, C1to C4alkyl, cycloalkyl, phenyl which may be substituted with a substituent, or methanesulfonyl.

Thromboxane Synthetase Inhibitors (TXSI). Design, Synthesis, and Evaluation of a Novel Series of ω-Pyridylalkenoic Acids

A novel series of ω-pyridylalkenoic acids has been prepared by applying the Wittig reaction.Modifications were made in the ω-aryl moiety, the alkylene chain length, the α-methylene group adjacent to the carbonyl group, and the carboxyl group in the molecu