96286-10-1

Usage

Uses

Used in Pharmaceutical Industry:
2-[1-(Dimethylamino)ethyl]indole is used as a key intermediate for the synthesis of pharmaceutical actives. Its unique structure allows it to be incorporated into the development of new drugs, potentially leading to the discovery of novel therapeutic agents with improved efficacy and safety profiles.
Used in Chemical Synthesis:
As a fine chemical, 2-[1-(Dimethylamino)ethyl]indole is utilized in the synthesis of various organic compounds. Its reactivity and functional groups make it a valuable building block for the creation of complex molecules, which can be applied in a wide range of chemical processes and industries.
Used in Research and Development:
2-[1-(Dimethylamino)ethyl]indole is also employed as a research chemical, enabling scientists to explore its properties and potential applications. Its unique structure and reactivity make it an interesting subject for studies in organic chemistry, medicinal chemistry, and materials science.

Upstream product

• 1477-50-5 Indole-2-carboxylic acid 
• 89671-83-0 1-(5-bromo-1H-indol-2-yl)ethan-1-one 
• 1016481-05-2 5-bromo-1H-indole-2-carboxylic acid N-methoxy-N-methyl amide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7254-19-5 5-bromo-2-indolecarboxylic acid 
• 96286-08-7 2-<1-(methylamino)ethyl>indole 
• 96286-09-8 2-<1-(N-formylmethylamino)ethyl>indole 
• 4264-35-1 2-acetylindole 

Relevant academic research and scientific papers

THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION

Disclosed herein are compounds of formula (I), or a salt thereof and compositions comprising compounds of formula I that exhibit antibacterial activities, when tested alone and/or in combination with a bacterial efflux pump inhibitor. Also disclosed are methods of treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I alone or in combination with the administration of a bacterial efflux pump inhibitor.

Synthesis of 3-Amino-5H-pyridoindoles, Carcinogenic γ-Carbolines

The carcinogenic γ-carbolines 3-amino-1,4-dimethyl-5H-pyridoindole (1) and 3-amino-1-methyl-5H-pyridoindole (2) were synthesized efficiently by the following procedures.The key method involved the acid-catalyzed cyclization of 2-acetamido-3-(2-indolyl)alkanoic acids to 1,2-dihydro-γ-carbolines.This was followed by dehydrogenation to the γ-carbolinecarboxylates and conversion of the ester group to the carboxyl and finally to the amino one by Curtius rearrangement.Alternative methods involved the thermolysis of 4-(1-benzotriazolyl)-3,6-dimethyl-2-pyridinamine to synthesize 1 and the condensation of 3-acetylindole-2-acetonitrile with ammonia to synthesize 2.The structures of γ-carbolines 1 and 2 were unambiguously established by comparing samples of each synthesized by the two different routes.A selective and one-step synthesis of ethyl 2-acetamido-3-(2-indolyl)alkanoates was newly exploited starting from diethyl acetamidomalonate and quaternary ammonium salts of 2-indoles.