896729-48-9Relevant articles and documents
4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors
Ni, Zhi-Jie,Barsanti, Paul,Brammeier, Nathan,Diebes, Anthony,Poon, Daniel J.,Ng, Simon,Pecchi, Sabina,Pfister, Keith,Renhowe, Paul A.,Ramurthy, Savithri,Wagman, Allan S.,Bussiere, Dirksen E.,Le, Vincent,Zhou, Yasheen,Jansen, Johanna M.,Ma, Sylvia,Gesner, Thomas G.
, p. 3121 - 3124 (2006)
CHK-1 is one of the key enzymes regulating checkpoints in cellular growth cycles. Novel 4-(amino-alkylamino)-3-benzimidazole-quinolinones were prepared and assayed for their ability to inhibit CHK-1. These compounds are potent cell permeable CHK-1 inhibit