3-(1H-benzimidazol-2-yl)-4-hydroxy-1-(4-methoxybenzyl)-6-chloro-1H-2-quinolinone

Base Information

• Chemical Name: 3-(1H-benzimidazol-2-yl)-4-hydroxy-1-(4-methoxybenzyl)-6-chloro-1H-2-quinolinone
• CAS No.: 896729-48-9
• Molecular Formula: C₂₄H₁₈ClN₃O₃
• Molecular Weight: 431.878
• Mol file: 896729-48-9.mol

Synonyms:3-(1H-benzimidazol-2-yl)-4-hydroxy-1-(4-methoxybenzyl)-6-chloro-1H-2-quinolinone

Chemical Property of 3-(1H-benzimidazol-2-yl)-4-hydroxy-1-(4-methoxybenzyl)-6-chloro-1H-2-quinolinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1H-benzimidazol-2-yl)-4-hydroxy-1-(4-methoxybenzyl)-6-chloro-1H-2-quinolinone

There total 1 articles about 3-(1H-benzimidazol-2-yl)-4-hydroxy-1-(4-methoxybenzyl)-6-chloro-1H-2-quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-Chloro-1-(4-methoxybenzyl)-1H-benzo[d][1,3]oxazine-2,4-dione (896729-45-6) + ethyl (1H-benzimidazol-2-yl)acetate (14741-71-0) → 3-(1H-benzimidazol-2-yl)-4-hydroxy-1-(4-methoxybenzyl)-6-chloro-1H-2-quinolinone (896729-48-9)

Guidance literature:

ethyl (1H-benzimidazol-2-yl)acetate; With lithium hexamethyldisilazane; In tetrahydrofuran;

6-Chloro-1-(4-methoxybenzyl)-1H-benzo[d][1,3]oxazine-2,4-dione; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2006.03.059

Reference yield:

3-(1H-benzimidazol-2-yl)-4-hydroxy-1-(4-methoxybenzyl)-6-chloro-1H-2-quinolinone (896729-48-9) + sodium hydrogencarbonate (144-55-8) → 6-chloro-1-[(4-methoxyphenyl)methyl]-2-oxo-3-{1-[(trifluoromethyl)sulfonyl]-benzimidazol-2-yl}-4-hydroquinolyl (trifluoromethyl)sulfonate (1360454-35-8)

Guidance literature:

With trifluoromethylsulfonic anhydride; pyridine; In dichloromethane; chloroform;

Reference yield:

3-(1H-benzimidazol-2-yl)-4-hydroxy-1-(4-methoxybenzyl)-6-chloro-1H-2-quinolinone (896729-48-9) + trifluoromethylsulfonic anhydride (358-23-6) → 6-chloro-1-[(4-methoxyphenyl)methyl]-2-oxo-3-{1-[(trifluoromethyl)sulfonyl]-benzimidazol-2-yl}-4-hydroquinolyl (trifluoromethyl)sulfonate (1360454-35-8)

Guidance literature:

With pyridine; In dichloromethane; at -5 ℃; for 1 - 4h;

upstream raw materials:

6-Chloro-1-(4-methoxybenzyl)-1H-benzo[d][1,3]oxazine-2,4-dione

ethyl (1H-benzimidazol-2-yl)acetate

Downstream raw materials:

6-chloro-1-[(4-methoxyphenyl)methyl]-2-oxo-3-{1-[(trifluoromethyl)sulfonyl]-benzimidazol-2-yl}-4-hydroquinolyl (trifluoromethyl)sulfonate