897-73-4

Usage

Uses

Used in Organic Chemistry:
2,4-dinitrophenyl piperidine-1-carbodithioate is used as a reagent for the detection of alcohols and phenols due to its ability to form bright yellow precipitates when reacting with specific functional groups. This property makes it useful for qualitative analysis and identification of these groups in various organic compounds.
Used in Pharmaceutical Research:
2,4-dinitrophenyl piperidine-1-carbodithioate is used as a research compound in the pharmaceutical industry, where it may have potential applications in drug development and synthesis. Its reactivity and unique properties can contribute to the discovery and design of new pharmaceutical agents.
However, it is important to handle 2,4-dinitrophenyl piperidine-1-carbodithioate with caution due to its toxic and irritant properties. Proper safety measures should be taken to minimize exposure and ensure the safe use of this chemical compound in research and industrial applications.

Upstream product

• 70-34-8 2,4-Dinitrofluorobenzene 
• 59983-55-0 triethylammonium piperidinodithiocarbamate 
• 110-89-4 piperidine 

Relevant academic research and scientific papers

Synthesis and pharmacological evaluation of 2,4-dinitroaryldithiocarbamate derivatives as novel monoacylglycerol lipase inhibitors

Monoacylglycerol lipase (MAGL) is responsible for signal termination of 2-arachidonoylglycerol (2-AG), an endocannabinoid neurotransmitter endowed with several physiological effects. Previously, we showed that the arylthioamide scaffold represents a privileged template for designing MAGL inhibitors. A series of 37 compounds resulting from pharmacomodulations around the arylthioamide template were synthesized and tested to evaluate their inhibitory potential on MAGL activity as well as their selectivity over fatty acid amide hydrolase (FAAH), another endocannabinoid-hydrolyzing enzyme. We have identified 2,4-dinitroaryldithiocarbamate derivatives as a novel class of MAGL inhibitors. Among the synthesized compounds, we identified [2,4-dinitrophenyl-4-(4-tert- butylbenzyl)piperazine-1-carbodithioate] (CK37), as the most potent MAGL inhibitor within this series (IC50 = 154 nM). We have also identified [2,4-dinitrophenyl-4-benzhydrylpiperazine-1-carbodithioate] (CK16) as a selective MAGL inhibitor. These compounds are irreversible MAGL inhibitors that probably act by interacting with Cys208 or Cys242 and Ser122 residues of the enzyme. Moreover, CK37 is able to raise 2-arachidonoylglycerol (2-AG) levels in intact cells.