897016-96-5Relevant academic research and scientific papers
SUBSTITUTED BENZAZINONES AS ANTIBACTERIAL COMPOUNDS
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Page/Page column 175, (2017/07/14)
The present invention relates to LpxC antibacterial compounds of Formula (1A), corresponding pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions:, compound preparation, treatment methods and uses for bacterial infections, especially those caused by gram-negative bacteria.
Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy
Baragana, Beatriz,Norcross, Neil R.,Wilson, Caroline,Porzelle, Achim,Hallyburton, Irene,Grimaldi, Raffaella,Osuna-Cabello, Maria,Norval, Suzanne,Riley, Jennifer,Stojanovski, Laste,Simeons, Frederick R. C.,Wyatt, Paul G.,Delves, Michael J.,Meister, Stephan,Duffy, Sandra,Avery, Vicky M.,Winzeler, Elizabeth A.,Sinden, Robert E.,Wittlin, Sergio,Frearson, Julie A.,Gray, David W.,Fairlamb, Alan H.,Waterson, David,Campbell, Simon F.,Willis, Paul,Read, Kevin D.,Gilbert, Ian H.
supporting information, p. 9672 - 9685 (2016/11/19)
The antiplasmodial activity, DMPK properties, and efficacy of a series of quinoline-4-carboxamides are described. This series was identified from a phenotypic screen against the blood stage of Plasmodium falciparum (3D7) and displayed moderate potency but with suboptimal physicochemical properties and poor microsomal stability. The screening hit (1, EC50 = 120 nM) was optimized to lead molecules with low nanomolar in vitro potency. Improvement of the pharmacokinetic profile led to several compounds showing excellent oral efficacy in the P. berghei malaria mouse model with ED90 values below 1 mg/kg when dosed orally for 4 days. The favorable potency, selectivity, DMPK properties, and efficacy coupled with a novel mechanism of action, inhibition of translation elongation factor 2 (PfEF2), led to progression of 2 (DDD107498) to preclinical development.
Anti-Malarial Agents
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Paragraph 0279-0281, (2015/02/25)
The present invention relates to a novel class of quinolone-4-carboxamide Pf3D7 inhibitors of general formula (I) (Formula (I)) wherein R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined herein, to their use in medicine, and in the treatment of malaria in particular, to compositions containing them, to processes for their preparation and to intermediates used in such processes.
ANTI-MALARIAL AGENTS
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Page/Page column 45; 46, (2013/11/05)
The present invention relates to a novel class of quinolone-4-carboxamide Pf3D7 inhibitors of general formula (I) (Formula (I)) wherein R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined herein, to their use in medicine, and in the treatment of malaria in particular, to compositions containing them, to processes for their preparation and to intermediates used in such processes.
Imidazole Substituted Pyrimidines
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, (2010/11/03)
A compound of formula (I) wherein R1 is hydrogen or fluoro; R2 and R3 are independently selected from hydrogen or methyl, or a pharmaceutically acceptable salt thereof; pharmaceutical formulations containing said compound; the use of said compound in therapy; the use for the treatment of conditions associated with glycogen synthase kinase-3 related disorders, such as Alzheimer's disease, as well as methods of treatment of said disorders, comprising administering to subjects in need of such treatment, a therapeutically effective amount of said compound.
Compositions and methods of treating cell proliferation disorders
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Page/Page column 84, (2008/06/13)
The invention relates to compounds and methods for treating cell proliferation disorders.
