897017-95-7

Upstream product

• 365572-23-2 2-(2-bromo-4-methoxy-5-(1-methylethoxy)benzene)ethanol 
• 867313-46-0 2-bromo-5-isopropoxy-4-methoxystyrene 
• 850346-69-9 2-(2-bromo-5-isopropoxy-4-methoxyphenyl)ethyl p-toluenesulfonate 
• 850346-72-4 methyl 8-isopropoxy-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate 
• 850346-70-2 methyl 1-[2-bromo-5-isopropoxy-4-methoxyphenethyl]-1H-pyrrole-2-carboxylate 
• 269410-22-2 4-hydroxy-3-methoxyphenylboronic acid pinacol ester 
• 850346-76-8 methyl 1,2-dibromo-8-isopropoxy-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate 
• 1193-62-0 methyl Pyrrole-2-carboxylate 

Downstream Products

• 897018-55-2 methyl 1,2-bis(4-hydroxy-3-methoxyphenyl)-8-isopropoxy-9-methoxypyrrolo[2,1-a]isoquinoline-3-carboxylate 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship study of potent cytotoxic analogues of the marine alkaloid lamellarin D

The marine alkaloid, Lamellarin D (Lam-D), has shown potent cytotoxicity in numerous cancer cell lines and was recently identified as a potent topoisomerase I inhibitor. A library of open lactone analogues of Lam-D was prepared from a methyl 5,6-dihydropy

5,6-Dihydropyrrolo[2,1-b]isoquinolines as scaffolds for synthesis of lamellarin analogues

Efficient modular synthetic routes to open chain marine alkaloids such as lamellarins have been developed. 5,6-Dihydropyrrolo[2,1-b]isoquinoline scaffolds were prepared, and protocols enabling regioselective bromination followed by Suzuki cross-coupling were established for the introduction of aryl groups onto the 2- and 3-positions.