365572-23-2Relevant articles and documents
Design and synthesis of lamellarin D analogues targeting topoisomerase I
Ohta, Takeshi,Fukuda, Tsutomu,Ishibashi, Fumito,Iwao, Masatomo
experimental part, p. 8143 - 8153 (2010/02/17)
(Chemical Equation Presented) A general synthetic route to rationally designed lamellarinDanalogues, 1-dearyllamellarinD(1) and 1-substituted 1-dearyllamellarin D (2), has been developed. The key pentacyclic intermediate 22 was prepared by palladium-catalyzed direct arylation of 12, which in turn was synthesized via C-2-selective lithiation of 15 followed by palladium-catalyzed cross-coupling as the key reactions. Compound 22 was converted to a wide range of C-1-substituted analogues 2 via regioselective electrophilic substitution and palladium-catalyzed cross-coupling reactions.
Di- and triarylsubstituted pyrroles by sequential regioselective cross-coupling reactions
Schroeter, Sven,Bach, Thorsten
, p. 569 - 594 (2008/09/18)
The di- and tribrominated pyrroles, such as methyl 3,4,5-tribromo- pyrrole-2-carboxylate (1), ethyl 3,4,5-tribromopyrrole-2-carboxylate (2), methyl 4,5-dibromopyrrole-2-carboxylate (3), and 4,5-dibromo-2-nitropyrrole (4), were prepared and evaluated for t
5,6-Dihydropyrrolo[2,1-b]isoquinolines as scaffolds for synthesis of lamellarin analogues
Olsen, Christian A.,Parera, Núria,Albericio, Fernando,álvarez, Mercedes
, p. 2041 - 2044 (2007/10/03)
Efficient modular synthetic routes to open chain marine alkaloids such as lamellarins have been developed. 5,6-Dihydropyrrolo[2,1-b]isoquinoline scaffolds were prepared, and protocols enabling regioselective bromination followed by Suzuki cross-coupling were established for the introduction of aryl groups onto the 2- and 3-positions.
4a,5,9,10,11,12-hexahydro-6H-benzo[a]cyclohepta[hi]benzo-furan - Synthesis of unnatural galanthamine analogs
Treu, Matthias,Jordis, Ulrich
, p. 374 - 381 (2007/10/03)
The synthesis of an unnatural galanthamine analog is reported.