897036-92-9

Basic information

• Product Name: 1-benzyl-3-methoxy-1H-pyrrole-2,5-dione
• Synonyms: 1-benzyl-3-methoxy-1H-pyrrole-2,5-dione
• CAS NO: 897036-92-9
• Molecular Weight: 217.224
• Mol File: 897036-92-9.mol

Chemical Properties

• CAS DataBase Reference: 1-benzyl-3-methoxy-1H-pyrrole-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-3-methoxy-1H-pyrrole-2,5-dione(897036-92-9)
• EPA Substance Registry System: 1-benzyl-3-methoxy-1H-pyrrole-2,5-dione(897036-92-9)

Safety Data

• Hazardous Substances Data: 897036-92-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 112749-49-2 3-bromo-2,5-dihydro-1-benzyl-1H-pyrrole-2,5-dione 
• 98027-61-3 3-methoxy-1H-pyrrole-2,5-dione 
• 100-44-7 benzyl chloride 

Downstream Products

• 1140906-26-8 C₁₃H₁₅NO₃ 
• 1140906-27-9 C₁₆H₂₁NO₃ 
• 524005-23-0 5-allyl-1-benzyl-4-methoxy-1H-pyrrol-2(5H)-one 
• 90968-37-9 1-Benzyl-4-methoxy-Δ³-pyrrolin-2-one 
• 897036-95-2 5-acetoxy-1-benzyl-4-methoxy-1H-pyrrol-2(5H)-one 
• 897036-94-1 1-benzyl-5-hydroxy-4-methoxy-1H-pyrrol-2(5H)-one 

Relevant articles and documents

Regioselective reduction of 3-methoxymaleimides: An efficient method for the synthesis of methyl 5-hydroxytetramates

3-Methoxymaleimide and various N-alkyl-3-methoxymaleimides, synthesized by base-promoted N-alkylation of 3-methoxymaleimide, were reduced using sodium borohydride with complete regioselectivity. The resultant methyl 5-hydroxytetramates are useful intermediates in the synthesis of a variety of tetramate derivatives.

A flexible approach to methyl (5S)-5-alkyltetramate derivatives

Regioselective Grignard reagent additions to 3-methoxymaleimides and subsequent diastereoselective reductive dehydroxylation of the resulting N,O-acetals were studied. On the basis of these studies, a flexible and highly regio- and diastereoselective approach to methyl 5-alkyltetramate derivatives was disclosed. The method is the first direct and flexible asymmetric cationic synthon-based approach, and allows for the synthesis of various methyl (5S)-5-alkyltetramate derivatives that are otherwise inaccessible by the commonly used methods based on α-amino acids. Georg Thieme Verlag Stuttgart.