89725-33-7Relevant academic research and scientific papers
Diuretic and antihypertensive benzimidazoles
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, (2008/06/13)
The invention relates to compounds which exhibit diuretic and antihypertensive properties and have the following structures: STR1 or pharmaceutically acceptable salts thereof, wherein: X=halogen or trifluoromethyl Y1 and Y2 =independently hydrogen, alkyl, acyl, aryl, substituted aryl or heterocycle, R1 =hydrogen, lower alkyl, aryl, substituted aryl, benzyl, substituted benzyl, aralkyl, heterocycle or substituted heterocycle, n=O or an integer from 1-4 R2 =amino, substituted amino, guanidino, substituted guanidino, halogen, alkyl, substituted alkyl, aryl, substituted aryl or heterocycle, and R3 =hydrogen, lower alkyl, aryl, substituted aryl, benzyl, substituted benzyl, aralkyl, heterocycle, substituted heterocycle or acyl.
