897376-76-0

Basic information

• Product Name: 4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester
• CAS NO: 897376-76-0
• Molecular Formula: C15H19F4N3O2
• Molecular Weight: 349.3238728
• Mol File: 897376-76-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester(897376-76-0)
• EPA Substance Registry System: 4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester(897376-76-0)

Safety Data

• Hazardous Substances Data: 897376-76-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester is utilized as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and the presence of the tert-butyl ester group contribute to its potential as a prodrug, which can be further developed to improve the solubility and bioavailability of the final drug product.
Used in Drug Formulation:
As a prodrug, 4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester is used to enhance the solubility and bioavailability of active pharmaceutical ingredients. This can lead to improved drug delivery and therapeutic efficacy, making it a valuable component in the development of novel drug formulations.
Further study and investigation are necessary to fully explore the potential uses and effects of this chemical, as its specific applications and benefits in various industries are not yet fully understood.

Upstream product

• 72600-67-0 2-chloro-3-fluoro-5-(trifluoromethyl)pyridine 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 89402-42-6 2,3-difluoro-5-(trifluoromethyl)pyridine 

Downstream Products

• 845616-81-1 1-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)piperazine 

Relevant articles and documents

MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2

The present application provides a compound of Formula: or a pharmaceutically acceptable salt thereof, wherein ring B, L1, ring A, L2, n, R1, R2, R3, R4, and X1 are as described herein. Pharmaceutical compositions comprising the compound, as well as the methods of making and using the compound, are also provided.

Selective GlyT1 inhibitors: Discovery of [4-(3-fluoro-5- trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2, 2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia

The GlyT1 transporter has emerged as a key novel target for the treatment of schizophrenia. Herein, we report on the optimization of the 2-alkoxy-5-methylsulfonebenzoylpiperazine class of GlyT1 inhibitors to improve hERG channel selectivity and brain penetration. This effort culminated in the discovery of compound 10a (RG1678), the first potent and selective GlyT1 inhibitor to have a beneficial effect in schizophrenic patients in a phase II clinical trial.

Sulfanyl substituted phenyl methanones

The present invention relates to compounds of formula I wherein R1, R2, R3, X, X1, and n are as defined in the specification and pharmaceutically acceptable acid addition salts thereof. These compounds are good inhibitors of the glycine transporter 1 (GlyT-1) for the treatment CNS disorders, such as schizophrenia, cognitive impairment, and Alzheimer's disease.