897399-74-5

Basic information

• Product Name: ETHYL 6-(PYRROLIDIN-1-YL)NICOTINATE
• Synonyms: ETHYL 6-(PYRROLIDIN-1-YL)NICOTINATE;ethyl 6-(1－pyrrolidinyl)nicotinate;2-(Pyrrolidin-1-yl)pyridine-5-carboxylic acid ethyl ester;6-(Pyrrolidin-1-yl)nicotinic acid ethyl ester;3-Pyridinecarboxylic acid, 6-(1-pyrrolidinyl)-, ethyl ester
• CAS NO: 897399-74-5
• Molecular Formula: C₁₂H₁₆N₂O₂
• Molecular Weight: 220.27
• Mol File: 897399-74-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 362.151 °C at 760 mmHg
• Flash Point: 172.823 °C
• Appearance: /
• Density: 1.149
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ETHYL 6-(PYRROLIDIN-1-YL)NICOTINATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 6-(PYRROLIDIN-1-YL)NICOTINATE(897399-74-5)
• EPA Substance Registry System: ETHYL 6-(PYRROLIDIN-1-YL)NICOTINATE(897399-74-5)

Safety Data

• Hazardous Substances Data: 897399-74-5(Hazardous Substances Data)

Synthetic route

pyrrolidine (123-75-1) + 6-chloro-3-pyridinecarboxylic acid ethyl ester (49608-01-7) → 6-pyrrolidin-1-yl-nicotinic acid ethyl ester (897399-74-5)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 60℃;	80%

6-pyrrolidin-1-yl-nicotinic acid ethyl ester (897399-74-5) → 6-(pyrrolidine-1-yl)nicotinic acid (210963-95-4)

Conditions	Yield
Stage #1: 6-pyrrolidin-1-yl-nicotinic acid ethyl ester With methanol; water; lithium hydroxide In tetrahydrofuran at 20℃; for 0.5h; Stage #2: With hydrogenchloride In water

Upstream product

• 123-75-1 pyrrolidine 
• 49608-01-7 6-chloro-3-pyridinecarboxylic acid ethyl ester 

Downstream Products

• 210963-95-4 6-(pyrrolidine-1-yl)nicotinic acid 

Relevant articles and documents

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE

The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.