897626-88-9Relevant academic research and scientific papers
O-selective condensation using P-N bond cleavage in RNA synthesis without base protection
Ohkubo, Akihiro,Kuwayama, Yasukazu,Kudo, Tomomi,Tsunoda, Hirosuke,Seio, Kohji,Sekine, Mitsuo
supporting information; experimental part, p. 2793 - 2796 (2009/06/06)
(Chemical Equation Presented) In RNA synthesis without base protection, a new method for O-selective condensation with more than 99% selectivity was developed by 6-nitro-HOBt-mediated cleavage of undesired P(III)-N bonds on nucleobase moieties. Moreover, we for the first time succeeded in synthesizing oligoRNAs without base protection.
