89777-91-3

Usage

Physical state

Colorless liquid

Odor

Distinct sweet odor

Usage

Solvent in various industrial processes

Importance

Intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds

Application

Reagent in organic synthesis

Function

Stabilizer for reactive intermediates

Potential applications

Development of new materials and as a precursor for the synthesis of specialty chemicals

Upstream product

• 17739-45-6 2-(2-bromoethoxy)tetrahydropyran 
• 451-40-1 phenyl benzyl ketone 

Downstream Products

• 177989-80-9 (Z)-(1-(4-(2-(benzyloxy)ethoxy)phenyl)-4-chlorobut-1-ene-1,2-diyl)dibenzene 
• 128607-22-7 ospemifene 

Relevant academic research and scientific papers

PROCESS FOR PREPARATION OF OSPEMIFENE

The present invention relates to a process for the preparation of ospemifene and pharmaceutically acceptable salts thereof which comprises the step of recycling the undesired E-4-(4-hydroxy-1,2-diphenylbut-1-enyl)phenol to generate an isomeric mixture of Z,E-4-(4-hydroxy-1,2-diphenylbut-1-enyl)phenol.

Triphenylalkene derivatives and their use as selective estrogen receptor modulators

The invention provides novel selective estrogen receptor modulator compounds of the general formula: wherein R1 and R2, which are the same or different are a) H, halogen, OCH3, OH; or ?where X is O, NH or S; and n is an integer from 1 to 4; and R4 and R5, which are the same or different, are a 1 to 4 carbon alkyl, H, —CH2C≡CH or —CH2CH2OH; or R4 and R5 form an N-containing five- or six-membered ring or heteroaromatic ring; or c) —Y—(CH2)nCH2—O—R6 where Y is O, NH or S and n is an integer from 1 to 4; and R6 is H, —CH2CH2OH, or —CH2CH2Cl; or d) 2,3-dihydroxypropoxy, 2-methylsulfamylethoxy, 2-chloroethoxy, 1-ethyl-2-hydroxyethoxy, 2,2-diethyl-2-hydroxyethoxy or carboxymethoxy; and R3 is H, halogen, OH or —OCH3; stereoisomers thereof and their non-toxic pharmaceutically acceptable salts and esters and mixtures thereof, which compounds exhibit valuable pharmacological properties.

Novel tri-phenyl alkane and alkene derivatives and their preparation and use

The invention provides novel compounds of the formula: STR1 wherein n is 0 to 4, R1 and R2, which can be the same or different are H, OH, alkoxy of 1 to 4 carbon atoms, benzyloxy or methoxymethoxy; R3 is H, OH, halogen, alkoxy of 1 to 4 carbon atoms, benzyloxy, methoxymethoxy, 2,3-dihydroxypropoxy or STR2 wherein m is 1 or 2, R6 and R7, which can be the same or different are H or an alkyl group of 1 to 4 carbon atoms, or STR3 can form an N-containing three-, four-, five- or six-membered heterocyclic ring; R4 is OH, F, Cl, Br, I, mesyloxy, tosyloxy, alkylcarbonyloxy of 1 to 4 C-atoms, formyloxy or CH2 R4 is replaced by CHO; R5 is H or OH; or R4 and R5 together form an --O-- bridge between the carbon atoms to which they are attached, and their non-toxic pharmaceutically acceptable salts and esters and mixtures thereof. Processes for the preparation of these compounds are described, and also novel pharmaceutical compositions containing them. These compounds exhibit valuable pharmacological properties as estrogenic, anti-estrogenic, and progestanic agents. They are also effective against oestrogen-dependent tumors. Certain compounds are useful as chemical intermediates for the preparation of pharmacologically active compounds of the invention.