89778-37-0

Upstream product

• 5650-41-9 3-hydroxy-1-phenylpropan-1-one 
• 1137-42-4 4-Hydroxybenzophenone 

Downstream Products

• 341526-07-6 (Z)-4-[4-(2-Methylsulfanylethoxy)phenyl]-3,4-diphenyl-but-3-en-1-ol 
• 89778-26-7 toremifene 
• 97151-03-6 (Z)-1,2-diphenyl-1-[4-[2-(N,N-dimethylamino)ethoxy]phenyl]-1-buten-4-ol 

Relevant academic research and scientific papers

Toremifene synthesis method

The invention provides a synthesis method of toremifene. The synthesis method comprises the following steps: S1. performing McMurry reaction to a compound B as shown in a structural formula II and a compound C as shown in a structural formula III, to obtain a compound D as shown in a structural formula IV; S2. performing selective alkylation reaction of phenolic hydroxyl to the compound D and a compound E as shown in a structural formula V or hydrochloride of the compound E, to obtain a compound F as shown in a structural formula VI; and S3. reacting the compound F with thionyl chloride, to obtain the toremifene, wherein the structural formula II, the structural formula III, the structural formula IV, the structural formula V and the structural formula VI are respectively shown in the specification. The obtained compound D has higher stereoselectivity, therefore, the reaction yield of the toremifene with a Z configuration can be increased when the compound D serves as an intermediate to synthesize the toremifene, and the purity of the toremifene with the Z configuration can be improved; and the synthesis method is stable in technology, mild in reaction conditions, the intermediate is easily separated, and the synthesis method can be used for mass production.

Serum cholesterol lowering agent

PCT No. PCT/FI97/00140 Sec. 371 Date Oct. 8, 1998 Sec. 102(e) Date Oct. 8, 1998 PCT Filed Mar. 4, 1997 PCT Pub. No. WO97/32574 PCT Pub. Date Sep. 12, 1997A method of lowering serum cholesterol levels comprising administering to a patient in need of such treatment an effective amount of Z-2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol, as well as pharmaceutical compositions useful in the method, is disclosed.

Triphenylethylenes for the prevention and treatment of osteoporosis

Compounds having formula (I) wherein R1 and R2 are independently H or OH, are useful in the treatment and prevention of osteoporosis. The compounds of formula (I) are devoid of significant antiestrogenic and estrogenic activity. STR1