97151-03-6

Basic information

• Product Name: 1,2-Diphenyl-1-[4-[2-(Dimethylamino) Ethoxy]-Phenyl] Butane-4-Ol
• Synonyms: 1,2-Diphenyl-1-[4-[2-(Dimethylamino) Ethoxy]-Phenyl] Butane-4-Ol;1,2-Diphenyl-1-4-2-(dimethylamino)ethoxyphenyl-1-butanol;1,2-Diphenyl-1-[4-[2-(Dimethylamino)ethoxy]phenyl]Butane-1,4-ol;Hydroxy-Toremifene;Double bond geometry as shown
• CAS NO: 97151-03-6
• Molecular Formula: C₂₆H₂₉NO₂
• Molecular Weight: 389.52984
• Product Categories: Amines;Aromatics;Drug Analogues;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 97151-03-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 105-107°C
• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Dichlormethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: 1,2-Diphenyl-1-[4-[2-(Dimethylamino) Ethoxy]-Phenyl] Butane-4-Ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Diphenyl-1-[4-[2-(Dimethylamino) Ethoxy]-Phenyl] Butane-4-Ol(97151-03-6)
• EPA Substance Registry System: 1,2-Diphenyl-1-[4-[2-(Dimethylamino) Ethoxy]-Phenyl] Butane-4-Ol(97151-03-6)

Safety Data

• Hazardous Substances Data: 97151-03-6(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

A hydroxylated analogue of Tamoxifen (T006000) with anti-estrogenic properties. A Tamoxifen derivatives for imaging and treatment of estrogen receptor-positive tumors.

Upstream product

• 89778-37-0 4-(4-hydroxyphenyl)-3,4-diphenyl-but-3-en-1-ol 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 5650-41-9 3-hydroxy-1-phenylpropan-1-one 
• 1137-42-4 4-Hydroxybenzophenone 
• 75-21-8 oxirane 
• 19076-79-0 (E/Z)-1-Bromo-2-[4-[2-(dimethylamino)ethoxy]phenyl]-1,2-diphenylethene 

Downstream Products

• 89778-26-7 toremifene 

Relevant articles and documents

Toremifene synthesis method

The invention provides a synthesis method of toremifene. The synthesis method comprises the following steps: S1. performing McMurry reaction to a compound B as shown in a structural formula II and a compound C as shown in a structural formula III, to obtain a compound D as shown in a structural formula IV; S2. performing selective alkylation reaction of phenolic hydroxyl to the compound D and a compound E as shown in a structural formula V or hydrochloride of the compound E, to obtain a compound F as shown in a structural formula VI; and S3. reacting the compound F with thionyl chloride, to obtain the toremifene, wherein the structural formula II, the structural formula III, the structural formula IV, the structural formula V and the structural formula VI are respectively shown in the specification. The obtained compound D has higher stereoselectivity, therefore, the reaction yield of the toremifene with a Z configuration can be increased when the compound D serves as an intermediate to synthesize the toremifene, and the purity of the toremifene with the Z configuration can be improved; and the synthesis method is stable in technology, mild in reaction conditions, the intermediate is easily separated, and the synthesis method can be used for mass production.