89780-29-0Relevant academic research and scientific papers
Azaanalogues of ebselen as antimicrobial and antiviral agents: Synthesis and properties
Wojtowicz,Kloc,Maliszewska,Mlochowski,Pietka,Piasecki
, p. 863 - 868 (2007/10/03)
The different analogues of ebselen - unsubstituted benzisoselenazol-3(2H)- one (2a) 2-pyridylbenzisoselenazol-3(2H)-ones (2b-h) and 7-azabenzisoselenazol- 3(2H)-ones (3a-j) were designed as new selenium-containing antiviral and antimicrobial agents and synthesized. Some of them were found in the antiviral assay in vitro to be strong inhibitors of cythopatic activity of herpes simplex virus type 1 - HSV-1 (compounds 2a,b,f,h, 3a-j) and encephalomyocarditis virus - EMCV (compounds 2a,h, 3a-f,k,l). The compounds 2a,h and 3a-e,j were found to have an appreciable activity against Gram-positive bacteria (Staphylococcus aureus and Bacillus) in vitro, some of them inhibited growth of pathogenic yeasts (Candida albicans) (3a,b) and filamentous fungi (3a-e,f).
Benzisoselenazolones and a process for the treatment of inflammatory diseases
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, (2008/06/13)
The invention relates to new benzisoselenazolones of the general formula I STR1 and a process for the treatment of humans suffering from inflammatory diseases of the rheumatic type.
