897918-34-2

Upstream product

• 413577-75-0 2-[4-(N-benzyloxycarbonylamino)-2-nitronaphthalen-1-yl]ethanol 
• 108-24-7 acetic anhydride 
• 2401-85-6 1-chloro-2,4-dinitronaphthalene 
• 897918-36-4 ditert-butyl (4-amino-2-nitronaphthalen-1-yl)-malonate 
• 897918-37-5 (4-amino-2-nitronaphthalen-1-yl) acetic acid 
• 413577-69-2 ethyl (4-amino-2-nitronaphthalen-1-yl)acetate 
• 413577-71-6 ethyl [4-(N-benzyloxycarbonylamino)-2-nitronaphthalen-1-yl]acetate 

Relevant academic research and scientific papers

Efficient synthesis of achiral seco-cyclopropylbenz[2,3-e]indoline analogues: [4-Amino-2-(5,6,7-trimethoxyindole-2-carboxamido)naphthalen-1-yl] ethyl chloride and [4-hydroxy-2-(5,6,7-trimethoxyindole-2-carboxamido) naphthalen-1-yl]ethyl chloride

Achiral seco-aminocyclopropylbenz[2,3-e]indoline and seco- hydroxycyclopropylbenz[2,3-e]indoline (seco-CBI) analogues of the duocarmycins and CC-1065, e.g., 7 and 8, are potent anticancer agents. This paper describes significantly improved synthetic strat